caa a22 4500 606201173 CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0670-z doi (NATIONALLICENCE)springer-10.1007/s00429-013-0670-z Functional changes during working memory in Huntington's disease: 30-month longitudinal data from the IMAGE-HD study [Elektronische Daten] [Govinda Poudel, Julie Stout, Juan Domínguez D, Marcus Gray, Louisa Salmon, Andrew Churchyard, Phyllis Chua, Beth Borowsky, Gary Egan, Nellie Georgiou-Karistianis] We characterized 30-month longitudinal change in functional activation and connectivity during working memory in premanifest (pre-HD) and symptomatic (symp-HD) Huntington's disease (HD). In acase-control longitudinal study (baseline, 18months, and 30months), wecompared change in fMRI activity over time during working memory in 22 pre-HD, 11 symp-HD, and 20 control participants. Outcome measures were BOLD (blood-oxygen-level-dependent) activity during 1-BACK and 2-BACK working memory and functional connectivity between dorsolateral prefrontal cortex (DLPFC) and caudate. Compared with controls, the pre-HD group showed significantly increased activation longitudinally during 1-BACK in the left DLPFC and medial frontal cortex, and further increased activation during 2-BACK in the bilateral caudate, putamen, and temporal cortex. Longitudinal change in symp-HD was not significantly different from controls. Longitudinal changes in pre-HD were associated with disease burden and years to onset. The pre-HD group showed longitudinal decreased functional connectivity between left DLPFC and caudate during both 1-BACK and 2-BACK performance. We provide an evidence for longitudinal changes in BOLD activity during working memory prior to clinical manifestations of HD. The ability to increase activation in the prefrontal cortex over time may represent an early compensatory response during the premanifest stage, which may reflect an early marker for clinically relevant functional changes in HD. Springer-Verlag Berlin Heidelberg, 2013 Functional connectivity nationallicence fMRI nationallicence Huntington's disease nationallicence Longitudinal nationallicence Working memory nationallicence Poudel Govinda School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Stout Julie School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Domínguez D Juan School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Gray Marcus Gehrmann Laboratory, Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, Australia aut Salmon Louisa School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Churchyard Andrew Department of Neurology, Monash Medical Centre, Clayton, VIC, Australia aut Chua Phyllis School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Borowsky Beth CHDI Management/CHDI Foundation, New York, NY, USA aut Egan Gary School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Georgiou-Karistianis Nellie School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 501-512 1863-2653 220:1<501 2015 220 429 https://doi.org/10.1007/s00429-013-0670-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0670-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poudel Govinda School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Stout Julie School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Domínguez D Juan School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Gray Marcus Gehrmann Laboratory, Centre for Advanced Imaging, The University of Queensland, St Lucia, QLD, Australia aut NATIONALLICENCE 700 1- Salmon Louisa School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Churchyard Andrew Department of Neurology, Monash Medical Centre, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Chua Phyllis School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Borowsky Beth CHDI Management/CHDI Foundation, New York, NY, USA aut NATIONALLICENCE 700 1- Egan Gary School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 700 1- Georgiou-Karistianis Nellie School of Psychology and Psychiatry, Monash University, 3800, Clayton, VIC, Australia aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 501-512 1863-2653 220:1<501 2015 220 429