caa a22 4500 60620119X CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0654-z doi (NATIONALLICENCE)springer-10.1007/s00429-013-0654-z Bimanual motor deficits in older adults predicted by diffusion tensor imaging metrics of corpus callosum subregions [Elektronische Daten] [L. Serbruyns, J. Gooijers, K. Caeyenberghs, R. Meesen, K. Cuypers, H. Sisti, A. Leemans, Stephan Swinnen] Age-related changes in the microstructural organization of the corpus callosum (CC) may explain declines in bimanual motor performance associated with normal aging. We used diffusion tensor imaging in young (n=33) and older (n=33) adults to investigate the microstructural organization of seven specific CC subregions (prefrontal, premotor, primary motor, primary sensory, parietal, temporal and occipital). A set of bimanual tasks was used to assess various aspects of bimanual motor functioning: the Purdue Pegboard test, simultaneous and alternating finger tapping, a choice reaction time test and a complex visuomotor tracking task. The older adults showed age-related deficits on all measures of bimanual motor performance. Correlation analyses within the older group showed that white matter fractional anisotropy of the CC occipital region was associated with bimanual fine manipulation skills (Purdue Pegboard test), whereas better performance on the other bimanual tasks was related to higher fractional anisotropy in the more anterior premotor, primary motor and primary sensory CC subregions. Such associations were less prominent in the younger group. Our findings suggest that structural alterations of subregional callosal fibers may account for bimanual motor declines in normal aging. Springer-Verlag Berlin Heidelberg, 2013 Aging nationallicence Bimanual coordination nationallicence Corpus callosum nationallicence DTI nationallicence Fractional anisotropy nationallicence AD : Axial diffusivity nationallicence CC : Corpus callosum nationallicence DTI : Diffusion tensor imaging nationallicence FA : Fractional anisotropy nationallicence ISO : Isofrequency ratios nationallicence N-ISO : Non-isofrequency ratios nationallicence OA : Older adults nationallicence RD : Radial diffusivity nationallicence YA : Young adults nationallicence Serbruyns L. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Gooijers J. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Caeyenberghs K. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Meesen R. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Cuypers K. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Sisti H. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Leemans A. Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands aut Swinnen Stephan Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 273-290 1863-2653 220:1<273 2015 220 429 https://doi.org/10.1007/s00429-013-0654-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0654-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Serbruyns L. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Gooijers J. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Caeyenberghs K. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Meesen R. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Cuypers K. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Sisti H. Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 700 1- Leemans A. Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands aut NATIONALLICENCE 700 1- Swinnen Stephan Motor Control Laboratory, Movement Control and Neuroplasticity Research Group, Biomedical Sciences Group, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 273-290 1863-2653 220:1<273 2015 220 429