caa a22 4500 606201203 CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0660-1 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0660-1 In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis [Elektronische Daten] [Nina Patzke, Muhammad Spocter, Karl Karlsson, Mads Bertelsen, Mark Haagensen, Richard Chawana, Sonja Streicher, Consolate Kaswera, Emmanuel Gilissen, Abdulaziz Alagaili, Osama Mohammed, Roger Reep, Nigel Bennett, Jerry Siegel, Amadi Ihunwo, Paul Manger] The hippocampus is essential for the formation and retrieval of memories and is a crucial neural structure sub-serving complex cognition. Adult hippocampal neurogenesis, thebirth, migration and integration of new neurons, is thought to contribute to hippocampal circuit plasticity to augment function. We evaluated hippocampal volume in relation to brain volume in 375 mammal species and examined 71 mammal species for the presence of adult hippocampal neurogenesis using immunohistochemistry for doublecortin, an endogenous marker of immature neurons that can be used as a proxy marker for the presence of adult neurogenesis. We identified that the hippocampus in cetaceans (whales, dolphins and porpoises) is both absolutely and relatively small for their overall brain size, and found that the mammalian hippocampus scaled as an exponential function in relation to brain volume. In contrast, the amygdala was found to scale as a linear function of brain volume, but again, the relative size of the amygdala in cetaceans was small. The cetacean hippocampus lacks staining for doublecortin in the dentate gyrus and thus shows no clear signs of adult hippocampal neurogenesis. This lack of evidence of adult hippocampal neurogenesis, along with the small hippocampus, questions current assumptions regarding cognitive abilities associated with hippocampal function in the cetaceans. These anatomical features of the cetacean hippocampus may be related to the lack of postnatal sleep, causing a postnatal cessation of hippocampal neurogenesis. Springer-Verlag Berlin Heidelberg, 2013 Adult hippocampal neurogenesis nationallicence Hippocampus nationallicence Doublecortin nationallicence Memory nationallicence Mammalia nationallicence Cognition nationallicence Patzke Nina School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut Spocter Muhammad School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut Karlsson Karl Biomedical Engineering, Reykjavik University, Menntavegur 1, 101, Reykjavik, Iceland aut Bertelsen Mads Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Frederiksberg, Denmark aut Haagensen Mark Department of Radiology, Donald Gordon Medical Centre, University of the Witwatersrand, Parktown, 2193, Johannesburg, South Africa aut Chawana Richard School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut Streicher Sonja Department of Zoology and Entomology, University of Pretoria, 0002, Pretoria, South Africa aut Kaswera Consolate Faculté des Sciences, University of Kisangani, B.P 1232, Kisangani, Democratic Republic of Congo aut Gilissen Emmanuel Department of African Zoology, Royal Museum for Central Africa, Leuvensesteenweg 13, 3080, Tervuren, Belgium aut Alagaili Abdulaziz KSU Mammals Research Chair, Department of Zoology, King Saud University, 11451, Riyadh, Saudi Arabia aut Mohammed Osama KSU Mammals Research Chair, Department of Zoology, King Saud University, 11451, Riyadh, Saudi Arabia aut Reep Roger Department of Physiological Sciences, University of Florida, 32610, Gainsville, FL, USA aut Bennett Nigel Department of Zoology and Entomology, University of Pretoria, 0002, Pretoria, South Africa aut Siegel Jerry Neurobiology Research, 151A3, Department of Psychiatry, Brain Research Institute, UCLA School of Medicine, Sepulveda VA Medical Centre, 91343, North Hills, CA, USA aut Ihunwo Amadi School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut Manger Paul School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 361-383 1863-2653 220:1<361 2015 220 429 https://doi.org/10.1007/s00429-013-0660-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0660-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patzke Nina School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut NATIONALLICENCE 700 1- Spocter Muhammad School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut NATIONALLICENCE 700 1- Karlsson Karl Biomedical Engineering, Reykjavik University, Menntavegur 1, 101, Reykjavik, Iceland aut NATIONALLICENCE 700 1- Bertelsen Mads Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Frederiksberg, Denmark aut NATIONALLICENCE 700 1- Haagensen Mark Department of Radiology, Donald Gordon Medical Centre, University of the Witwatersrand, Parktown, 2193, Johannesburg, South Africa aut NATIONALLICENCE 700 1- Chawana Richard School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut NATIONALLICENCE 700 1- Streicher Sonja Department of Zoology and Entomology, University of Pretoria, 0002, Pretoria, South Africa aut NATIONALLICENCE 700 1- Kaswera Consolate Faculté des Sciences, University of Kisangani, B.P 1232, Kisangani, Democratic Republic of Congo aut NATIONALLICENCE 700 1- Gilissen Emmanuel Department of African Zoology, Royal Museum for Central Africa, Leuvensesteenweg 13, 3080, Tervuren, Belgium aut NATIONALLICENCE 700 1- Alagaili Abdulaziz KSU Mammals Research Chair, Department of Zoology, King Saud University, 11451, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Mohammed Osama KSU Mammals Research Chair, Department of Zoology, King Saud University, 11451, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Reep Roger Department of Physiological Sciences, University of Florida, 32610, Gainsville, FL, USA aut NATIONALLICENCE 700 1- Bennett Nigel Department of Zoology and Entomology, University of Pretoria, 0002, Pretoria, South Africa aut NATIONALLICENCE 700 1- Siegel Jerry Neurobiology Research, 151A3, Department of Psychiatry, Brain Research Institute, UCLA School of Medicine, Sepulveda VA Medical Centre, 91343, North Hills, CA, USA aut NATIONALLICENCE 700 1- Ihunwo Amadi School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut NATIONALLICENCE 700 1- Manger Paul School of Anatomical Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2193, Johannesburg, South Africa aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 361-383 1863-2653 220:1<361 2015 220 429