caa a22 4500 606201246 CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0657-9 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0657-9 Gray and white matter structures in the midcingulate cortex region contribute to body mass index in Chinese young adults [Elektronische Daten] [Qinghua He, Chuansheng Chen, Qi Dong, Gui Xue, Chunhui Chen, Zhong-Lin Lu, Antoine Bechara] Overweight and obesity are rapidly becoming a central public health challenge around the world. Previous studies have suggested that elevated Body Mass Index (BMI) might be associated with structural changes in both gray and white matter, but this association is still not well understood. The present study aimed to investigate the relationship between BMI and brain structure with a relatively large sample of young adults (N=336) in a small age range (20±1years). Voxel-based morphometry results showed significant negative correlations between BMI and gray-matter volumes in the midcingulate cortex (MCC), left orbital frontal cortex, and left ventromedial prefrontal cortex. There was also a significant negative correlation between BMI and white matter integrity as indexed by fractional anisotropy in bilateral cingulum. Further tractography analysis showed a significant negative correlation between BMI and the number of fibers passing the MCC region. Regression analysis showed that gray matter and white matter in these regions both contributed to the variance of BMI. These results remained significant even when analysis was restricted to the subjects with normal weights. Finally, we found that decision-making ability (as assessed by the Iowa Gambling Task) mediated the association between the structure of the MCC (a region responsible for impulse control and decision making) and BMI. These results shed light on the structural neural basis of weight variations. Springer-Verlag Berlin Heidelberg, 2013 Obesity nationallicence Overweight nationallicence Midcingulate cortex (MCC) nationallicence Cingulum nationallicence Voxel-based morphometry (VBM) nationallicence Diffusion tensor imaging (DTI) nationallicence Tractography nationallicence The Iowa gambling task (IGT) nationallicence He Qinghua Faculty of Psychology, Southwest University (SWU), Beibei, 400715, Chongqing, China aut Chen Chuansheng Department of Psychology and Social Behavior, University of California, Irvine, 92697, Irvine, CA, USA aut Dong Qi National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China aut Xue Gui National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China aut Chen Chunhui National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China aut Lu Zhong-Lin Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, 43210, Columbus, OH, USA aut Bechara Antoine Brain and Creativity Institute, University of Southern California, 90089, Los Angeles, CA, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 319-329 1863-2653 220:1<319 2015 220 429 https://doi.org/10.1007/s00429-013-0657-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0657-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- He Qinghua Faculty of Psychology, Southwest University (SWU), Beibei, 400715, Chongqing, China aut NATIONALLICENCE 700 1- Chen Chuansheng Department of Psychology and Social Behavior, University of California, Irvine, 92697, Irvine, CA, USA aut NATIONALLICENCE 700 1- Dong Qi National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Xue Gui National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Chen Chunhui National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Lu Zhong-Lin Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Bechara Antoine Brain and Creativity Institute, University of Southern California, 90089, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 319-329 1863-2653 220:1<319 2015 220 429