caa a22 4500 606201297 CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0655-y doi (NATIONALLICENCE)springer-10.1007/s00429-013-0655-y Optic radiation structure and anatomy in the normally developing brain determined using diffusion MRI and tractography [Elektronische Daten] [Michael Dayan, Monica Munoz, Sebastian Jentschke, Martin Chadwick, Janine Cooper, Kate Riney, Faraneh Vargha-Khadem, Chris Clark] The optic radiation (OR) is a component of the visual system known to be myelin mature very early in life. Diffusion tensor imaging (DTI) and its unique ability to reconstruct the OR in vivo were used to study structural maturation through analysis of DTI metrics in a cohort of 90 children aged 5-18years. As the OR is at risk of damage during epilepsy surgery, we measured its position relative to characteristic anatomical landmarks. Anatomical distances, DTI metrics and volume of the OR were investigated for age, gender and hemisphere effects. We observed changes in DTI metrics with age comparable to known trajectories in other white matter tracts. Left lateralization of DTI metrics was observed that showed a gender effect in lateralization. Sexual dimorphism of DTI metrics in the right hemisphere was also found. With respect to OR dimensions, volume was shown to be right lateralised and sexual dimorphism demonstrated for the extent of the left OR. The anatomical results presented for the OR have potentially important applications for neurosurgical planning. The Author(s), 2013 Probabilistic tractography nationallicence Diffusion imaging nationallicence DTI nationallicence Optic radiation nationallicence Maturation nationallicence Brain nationallicence Meyer's loop nationallicence Lateral geniculate nucleus nationallicence Epilepsy surgery nationallicence Neurosurgery planning nationallicence Dayan Michael Imaging and Biophysics Unit, UCL Institute of Child Health, London, UK aut Munoz Monica Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK aut Jentschke Sebastian Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK aut Chadwick Martin Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK aut Cooper Janine Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK aut Riney Kate Neurosciences Unit, Mater Children's Hospital, South Brisbane, Australia aut Vargha-Khadem Faraneh Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK aut Clark Chris Imaging and Biophysics Unit, UCL Institute of Child Health, London, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 291-306 1863-2653 220:1<291 2015 220 429 https://doi.org/10.1007/s00429-013-0655-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0655-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dayan Michael Imaging and Biophysics Unit, UCL Institute of Child Health, London, UK aut NATIONALLICENCE 700 1- Munoz Monica Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Jentschke Sebastian Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK aut NATIONALLICENCE 700 1- Chadwick Martin Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK aut NATIONALLICENCE 700 1- Cooper Janine Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Riney Kate Neurosciences Unit, Mater Children's Hospital, South Brisbane, Australia aut NATIONALLICENCE 700 1- Vargha-Khadem Faraneh Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health, London, UK aut NATIONALLICENCE 700 1- Clark Chris Imaging and Biophysics Unit, UCL Institute of Child Health, London, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 291-306 1863-2653 220:1<291 2015 220 429