caa a22 4500 606201327 CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0665-9 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0665-9 Deficits in memory and visuospatial learning correlate with regional hippocampal atrophy in MS [Elektronische Daten] [Giulia Longoni, Maria Rocca, Elisabetta Pagani, Gianna Riccitelli, Bruno Colombo, Mariaemma Rodegher, Andrea Falini, Giancarlo Comi, Massimo Filippi] The hippocampus has a critical role in episodic memory and visuospatial learning and consolidation. We assessed the patterns of whole and regional hippocampal atrophy in a large group of multiple sclerosis (MS) patients, and their correlations with neuropsychological impairment. From 103 MS patients and 28 healthy controls (HC), brain dual-echo and high-resolution 3D T1-weighted images were acquired using a 3.0-Tesla scanner. All patients underwent a neuropsychological assessment of hippocampal-related cognitive functions, including Paired Associate Word Learning, Short Story, delayed recall of Rey-Osterrieth Complex Figure and Paced Auditory Serial Attention tests. The hippocampi were manually segmented and volumes derived. Regional atrophy distribution was assessed using a radial mapping analysis. Correlations between hippocampal atrophy and clinical, neuropsychological and MRI metrics were also evaluated. Hippocampal volume was reduced in MS patients vs HC (p<0.001 for both right and hippocampus). In MS patients, radial atrophy affected CA1 subfield and subiculum of posterior hippocampus, bilaterally. The dentate hilus (DG:H) of the right hippocampal head was also affected. Regional hippocampal atrophy correlated with brain T2 and T1 lesion volumes, while no correlation was found with disability. Damage to the CA1 and subiculum was significantly correlated to the performances at hippocampal-targeted neuropsychological tests. These results show that hippocampal subregions have a different vulnerability to MS-related damage, with a relative sparing of the head of the left hippocampus. The assessment of regional hippocampal atrophy may help explain deficits of specific cognitive functions in MS patients, including memory and visuospatial abilities. Springer-Verlag Berlin Heidelberg, 2013 Hippocampus nationallicence Radial mapping nationallicence Multiple sclerosis nationallicence Magnetic resonance imaging nationallicence Cognitive impairment nationallicence Longoni Giulia Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut Rocca Maria Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut Pagani Elisabetta Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut Riccitelli Gianna Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut Colombo Bruno Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut Rodegher Mariaemma Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut Falini Andrea Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut Comi Giancarlo Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut Filippi Massimo Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 435-444 1863-2653 220:1<435 2015 220 429 https://doi.org/10.1007/s00429-013-0665-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0665-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Longoni Giulia Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Rocca Maria Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Pagani Elisabetta Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Riccitelli Gianna Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 700 1- Colombo Bruno Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut NATIONALLICENCE 700 1- Rodegher Mariaemma Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut NATIONALLICENCE 700 1- Falini Andrea Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut NATIONALLICENCE 700 1- Comi Giancarlo Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy aut NATIONALLICENCE 700 1- Filippi Massimo Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 435-444 1863-2653 220:1<435 2015 220 429