caa a22 4500 606201335 CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0649-9 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0649-9 Action selection in a possible model of striatal medium spiny neuron dysfunction: behavioral and EEG data in a patient with benign hereditary chorea [Elektronische Daten] [Christian Beste, Carsten Saft] Chaining or cascading of different actions and responses is necessary to accomplish a goal. Yet, little is known about the functional neuroanatomical-electrophysiological mechanisms mediating these processes. Computational models suggest that medium spiny neurons (MSNs) play an important role in action cascading, but this assumption has hardly been tested relating neuroanatomical and electrophysiological parameters in a human model of circumscribed MSN dysfunction. As a possible human model of circumscribed MSN dysfunction, we investigate benign hereditary chorea in a case-control study applying bootstrap statistics. To investigate these mechanisms, we used a stop-change paradigm, where we apply mathematical constraints to describe the degree of how task goals are activated with more or less overlap during action cascading. We record event-related potentials and analyze neural synchronization processes. The results show that MSN dysfunctions lead to deficits in action cascading processes only when two response options seek simultaneous access to response selection resources. Attentional selection processes are not affected, but processes reflecting the transition between stimulus evaluation and responding are affected. The results underline computational models of MSN functioning and show that dysfunction in these networks leads to a more parallel and hence inefficient response selection. Springer-Verlag Berlin Heidelberg, 2013 Action control nationallicence Response selection nationallicence EEG nationallicence Benign hereditary chorea nationallicence Medium spiny neurons nationallicence Beste Christian Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, University of Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut Saft Carsten Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 221-228 1863-2653 220:1<221 2015 220 429 https://doi.org/10.1007/s00429-013-0649-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0649-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beste Christian Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, University of Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut NATIONALLICENCE 700 1- Saft Carsten Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 221-228 1863-2653 220:1<221 2015 220 429