caa a22 4500 60620136X CHVBK 20210128100947.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0652-1 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0652-1 Shifted neuronal balance during stimulus-response integration in schizophrenia: an fMRI study [Elektronische Daten] [Edna Cieslik, Veronika Müller, Tanja Kellermann, Christian Grefkes, Sarah Halfter, Simon Eickhoff] Schizophrenia is characterized by marked deficits in executive and psychomotor functions, as demonstrated for goal-directed actions in the antisaccade task. Recent studies, however, suggest that this deficit represents only one manifestation of a general deficit in stimulus-response integration and volitional initiation of motor responses. We here used functional magnetic resonance imaging to investigate brain activation patterns during a manual stimulus-response compatibility task in 18 schizophrenic patients and 18 controls. We found that across groups incongruent vs. congruent responses recruited a bilateral network consisting of dorsal fronto-parietal circuits as well as bilateral anterior insula, dorsolateral prefrontal cortex (DLPFC) and the presupplementary motor area (preSMA). When testing for the main-effect across all conditions, patients showed significantly lower activation of the right DLPFC and, in turn, increased activation in a left hemispheric network including parietal and premotor areas as well as the preSMA. For incongruent responses patients showed significantly increased activation in a similar left hemispheric network, as well as additional activation in parietal and premotor regions in the right hemisphere. The present study reveals that hypoactivity in the right DLPFC in schizophrenic patients is accompanied by hyperactivity in several fronto-parietal regions associated with task execution. Impaired top-down control due to a dysfunctional DLPFC might thus be partly compensated by an up-regulation of task-relevant regions in schizophrenic patients. Springer-Verlag Berlin Heidelberg, 2013 fMRI nationallicence Hypo-/hyperactivation nationallicence Prefrontal nationallicence Parietal nationallicence Manual nationallicence Executive control nationallicence Cieslik Edna Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut Müller Veronika Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut Kellermann Tanja Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut Grefkes Christian Neuromodulation and Neurorehabilitation, Max-Planck Institute for Neurological Research, Cologne, Germany aut Halfter Sarah Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, Germany aut Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 249-261 1863-2653 220:1<249 2015 220 429 https://doi.org/10.1007/s00429-013-0652-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0652-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cieslik Edna Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Müller Veronika Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Kellermann Tanja Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Grefkes Christian Neuromodulation and Neurorehabilitation, Max-Planck Institute for Neurological Research, Cologne, Germany aut NATIONALLICENCE 700 1- Halfter Sarah Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, Germany aut NATIONALLICENCE 700 1- Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 249-261 1863-2653 220:1<249 2015 220 429