caa a22 4500 606201378 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0675-7 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0675-7 Hippocampal 5-HT1A receptor binding is related to object-location memory in humans [Elektronische Daten] [Yifat Glikmann-Johnston, Michael Saling, Jian Chen, Graeme O'Keefe, Sylvia Gong, Henri Tochon-Danguy, Rachel Mulligan, David Reutens] Animal studies suggest that serotonin, mediated by the 5-HT1A receptor, plays a key role in spatial learning and memory. The role of serotonin in spatial memory in humans has, however, been less well studied. This study examined the relationship between serotonin receptor density in the human brain and spatial learning and memory using the 5-HT1A receptor ligand 18F-4-(2′-methoxyphenyl)-1-[2′-(N-2-pyridinyl)-p-fluorobenzamido]-ethyl-piperazine ([18F] MPPF) and positron emission tomography (PET). Ten neurologically healthy individuals underwent two [18F] MPPF PET scans, one while performing a task which involves processing of high-level spatial information (‘house scan'), and one while performing a task which involves processing of low-level spatial information (‘tunnel scan'). Navigation, recall of arbitrary associations between objects and their spatial location, and ability to draw a plan of the environment were tested following the house scan. 5-HT1A receptor binding did not differ significantly between processing high and low levels of spatial information. Hippocampal asymmetry in [18F] MPPF binding, however, was associated with memory for object-location associations; lower right than left hippocampal binding potential (BPND) was related to better memory performance. We conclude that hippocampal serotonergic function plays a role in a fundamental component of human spatial memory, the ability to recall the location of encountered objects. Springer-Verlag Berlin Heidelberg, 2014 Serotonin 1A receptor nationallicence Positron emission tomography nationallicence [18F] MPPF nationallicence Hippocampus nationallicence Spatial cognition nationallicence Navigation nationallicence Virtual environment nationallicence Glikmann-Johnston Yifat The School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel aut Saling Michael Psychological Sciences, The University of Melbourne, Melbourne, Australia aut Chen Jian Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Australia aut O'Keefe Graeme Centre for PET, Austin Health, Melbourne, Australia aut Gong Sylvia Centre for PET, Austin Health, Melbourne, Australia aut Tochon-Danguy Henri Centre for PET, Austin Health, Melbourne, Australia aut Mulligan Rachel Centre for PET, Austin Health, Melbourne, Australia aut Reutens David Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 559-570 1863-2653 220:1<559 2015 220 429 https://doi.org/10.1007/s00429-013-0675-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0675-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Glikmann-Johnston Yifat The School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Saling Michael Psychological Sciences, The University of Melbourne, Melbourne, Australia aut NATIONALLICENCE 700 1- Chen Jian Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Monash University, Melbourne, Australia aut NATIONALLICENCE 700 1- O'Keefe Graeme Centre for PET, Austin Health, Melbourne, Australia aut NATIONALLICENCE 700 1- Gong Sylvia Centre for PET, Austin Health, Melbourne, Australia aut NATIONALLICENCE 700 1- Tochon-Danguy Henri Centre for PET, Austin Health, Melbourne, Australia aut NATIONALLICENCE 700 1- Mulligan Rachel Centre for PET, Austin Health, Melbourne, Australia aut NATIONALLICENCE 700 1- Reutens David Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 559-570 1863-2653 220:1<559 2015 220 429