caa a22 4500 606201467 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0641-4 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0641-4 Multivariate classification of social anxiety disorder using whole brain functional connectivity [Elektronische Daten] [Feng Liu, Wenbin Guo, Jean-Paul Fouche, Yifeng Wang, Wenqin Wang, Jurong Ding, Ling Zeng, Changjian Qiu, Qiyong Gong, Wei Zhang, Huafu Chen] Recent research has shown that social anxiety disorder (SAD) is accompanied by abnormalities in brain functional connections. However, these findings are based on group comparisons, and, therefore, little is known about whether functional connections could be used in the diagnosis of an individual patient with SAD. Here, we explored the potential of the functional connectivity to be used for SAD diagnosis. Twenty patients with SAD and 20 healthy controls were scanned using resting-state functional magnetic resonance imaging. The whole brain was divided into 116 regions based on automated anatomical labeling atlas. The functional connectivity between each pair of regions was computed using Pearson's correlation coefficient and used as classification feature. Multivariate pattern analysis was then used to classify patients from healthy controls. The pattern classifier was designed using linear support vector machine. Experimental results showed a correct classification rate of 82.5% (p<0.001) with sensitivity of 85.0% and specificity of 80.0%, using a leave-one-out cross-validation method. It was found that the consensus connections used to distinguish SAD were largely located within or across the default mode network, visual network, sensory-motor network, affective network, and cerebellar regions. Specifically, the right orbitofrontal region exhibited the highest weight in classification. The current study demonstrated that functional connectivity had good diagnostic potential for SAD, thus providing evidence for the possible use of whole brain functional connectivity as a complementary tool in clinical diagnosis. In addition, this study confirmed previous work and described novel pathophysiological mechanisms of SAD. Springer-Verlag Berlin Heidelberg, 2013 Social anxiety disorder/social phobia nationallicence Multivariate pattern analysis nationallicence Support vector machine nationallicence Functional connectivity nationallicence Resting-state fMRI nationallicence Consensus features nationallicence Liu Feng Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut Guo Wenbin Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut Fouche Jean-Paul Department of Psychiatry, University of Cape Town, Cape Town, South Africa aut Wang Yifeng Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut Wang Wenqin School of Mathematical Sciences, University of Electronic Science and Technology of China, 611731, Chengdu, Sichuan, People's Republic of China aut Ding Jurong Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut Zeng Ling Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut Qiu Changjian Department of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China aut Gong Qiyong Department of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China aut Zhang Wei Department of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China aut Chen Huafu Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 101-115 1863-2653 220:1<101 2015 220 429 https://doi.org/10.1007/s00429-013-0641-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0641-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Feng Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Guo Wenbin Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, 530021, Nanning, Guangxi, People's Republic of China aut NATIONALLICENCE 700 1- Fouche Jean-Paul Department of Psychiatry, University of Cape Town, Cape Town, South Africa aut NATIONALLICENCE 700 1- Wang Yifeng Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Wang Wenqin School of Mathematical Sciences, University of Electronic Science and Technology of China, 611731, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Ding Jurong Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Zeng Ling Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 700 1- Qiu Changjian Department of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China aut NATIONALLICENCE 700 1- Gong Qiyong Department of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Wei Department of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China aut NATIONALLICENCE 700 1- Chen Huafu Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People's Republic of China aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 101-115 1863-2653 220:1<101 2015 220 429