caa a22 4500 606201483 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0886-6 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0886-6 Synchronization among neuronal pools without common inputs: in vivo study [Elektronische Daten] [Haya Brama, Shoshana Guberman, Moshe Abeles, Edward Stern, Ido Kanter] Periodic synchronization of activity among neuronal pools has been related to substantial neural processes and information throughput in the neocortical network. However, the mechanisms of generating such periodic synchronization among distributed pools of neurons remain unclear. We hypothesize that to a large extent there is interplay between the topology of the neocortical networks and their reverberating modes of activity. The firing synchronization is governed by a nonlocal mechanism, the network delay loops, such that distant neuronal pools without common drives can be synchronized. This theoretical interplay between network topology and the synchronized mode is verified using an iterative procedure of a single intracellularly recorded neuron in vivo, imitating the dynamics of the entire network. The input is injected to the neuron via the recording electrode as current and computed from the filtered, evoked spikes of its pre-synaptic sources, previously emulated by the same neuron. In this manner we approximate subthreshold synaptic inputs from afferent neuronal pools to the neuron. Embedding the activity of these recurrent motifs in the intact brain allows us to measure the effects of connection probability, synaptic strength, and ongoing activity on the neuronal synchrony. Our in vivo experiments indicate that an initial stimulus given to a single pool is dynamically evolving into the formations of zero-lag and cluster synchronization. By applying results from theoretical models and in vitro experiments to in vivo activity in the intact brain, we support the notion that this mechanism may account for the binding activity across distributed brain areas. Springer-Verlag Berlin Heidelberg, 2014 In vivo nationallicence Cell assemblies nationallicence Population dynamics nationallicence Neural networks nationallicence Synchronization nationallicence Brama Haya Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut Guberman Shoshana Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut Abeles Moshe Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut Stern Edward Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut Kanter Ido Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3721-3731 1863-2653 220:6<3721 2015 220 429 https://doi.org/10.1007/s00429-014-0886-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0886-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brama Haya Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut NATIONALLICENCE 700 1- Guberman Shoshana Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut NATIONALLICENCE 700 1- Abeles Moshe Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut NATIONALLICENCE 700 1- Stern Edward Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut NATIONALLICENCE 700 1- Kanter Ido Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University, 52900, Ramat Gan, Israel aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3721-3731 1863-2653 220:6<3721 2015 220 429