caa a22 4500 606201491 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0865-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0865-y Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development [Elektronische Daten] [Salma Hosseiny, Mariel Pietri, Agnès Petit-Paitel, Hadi Zarif, Catherine Heurteaux, Joëlle Chabry, Alice Guyon] Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8weeks old) for 4weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. Springer-Verlag Berlin Heidelberg, 2014 Enriched environment nationallicence Hippocampus neurogenesis and synaptogenesis nationallicence Long-term potentiation nationallicence Excitatory postsynaptic currents nationallicence Postnatal development nationallicence Hosseiny Salma Université de Nice Sophia Antipolis, 06103, Nice, France aut Pietri Mariel Université de Nice Sophia Antipolis, 06103, Nice, France aut Petit-Paitel Agnès Université de Nice Sophia Antipolis, 06103, Nice, France aut Zarif Hadi Université de Nice Sophia Antipolis, 06103, Nice, France aut Heurteaux Catherine Université de Nice Sophia Antipolis, 06103, Nice, France aut Chabry Joëlle Université de Nice Sophia Antipolis, 06103, Nice, France aut Guyon Alice Université de Nice Sophia Antipolis, 06103, Nice, France aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3435-3448 1863-2653 220:6<3435 2015 220 429 https://doi.org/10.1007/s00429-014-0865-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0865-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hosseiny Salma Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 700 1- Pietri Mariel Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 700 1- Petit-Paitel Agnès Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 700 1- Zarif Hadi Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 700 1- Heurteaux Catherine Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 700 1- Chabry Joëlle Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 700 1- Guyon Alice Université de Nice Sophia Antipolis, 06103, Nice, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3435-3448 1863-2653 220:6<3435 2015 220 429