caa a22 4500 606201513 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0852-3 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0852-3 Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development [Elektronische Daten] [Klára Marečková, Mallar Chakravarty, Claire Lawrence, Gabriel Leonard, Daniel Perusse, Michel Perron, Bruce Pike, Louis Richer, Suzanne Veillette, Zdenka Pausova, Tomáš Paus] We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n=119, 8years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen's d=0.76). Subsequently, we tested the possibility that this craniofacial "signature” of prenatal exposure to androgens predicts brain size, a known sexually dimorphic trait. In an independent sample of female adolescents (singletons; n=462), we found that the facial signature predicts up to 8% of variance in brain size. These findings are consistent with the organizational effects of androgens on brain development and suggest that the facial signature derived in this study could complement other indirect measures of prenatal exposure to androgens. Springer-Verlag Berlin Heidelberg, 2014 Prenatal androgens nationallicence Twins nationallicence Adolescents nationallicence MRI nationallicence Face nationallicence Brain nationallicence Marečková Klára Rotman Research Institute, University of Toronto, 3560 Bathurst Street, M6A 2E1, Toronto, ON, Canada aut Chakravarty Mallar Rotman Research Institute, University of Toronto, 3560 Bathurst Street, M6A 2E1, Toronto, ON, Canada aut Lawrence Claire School of Psychology, University of Nottingham, NG72RD, Nottingham, UK aut Leonard Gabriel Montréal Neurological Institute, McGill University, H3A 2B4, Montréal, QC, Canada aut Perusse Daniel CHU Sainte-Justine, 3175 Chemin de la Cote, Sainte-Catherine, H3T 1C5, Montreal, QC, Canada aut Perron Michel ECOBES, Recherche et transfert, Cegep de Jonquière, G7X 3W1, Jonquière, QC, Canada aut Pike Bruce Département des sciences de la santé, Université du Québec à Chicoutimi, G7H 2B1, Chicoutimi, QC, Canada aut Richer Louis Département des sciences de la santé, Université du Québec à Chicoutimi, G7H 2B1, Chicoutimi, QC, Canada aut Veillette Suzanne ECOBES, Recherche et transfert, Cegep de Jonquière, G7X 3W1, Jonquière, QC, Canada aut Pausova Zdenka School of Psychology, University of Nottingham, NG72RD, Nottingham, UK aut Paus Tomáš Rotman Research Institute, University of Toronto, 3560 Bathurst Street, M6A 2E1, Toronto, ON, Canada aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3233-3244 1863-2653 220:6<3233 2015 220 429 https://doi.org/10.1007/s00429-014-0852-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0852-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marečková Klára Rotman Research Institute, University of Toronto, 3560 Bathurst Street, M6A 2E1, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Chakravarty Mallar Rotman Research Institute, University of Toronto, 3560 Bathurst Street, M6A 2E1, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Lawrence Claire School of Psychology, University of Nottingham, NG72RD, Nottingham, UK aut NATIONALLICENCE 700 1- Leonard Gabriel Montréal Neurological Institute, McGill University, H3A 2B4, Montréal, QC, Canada aut NATIONALLICENCE 700 1- Perusse Daniel CHU Sainte-Justine, 3175 Chemin de la Cote, Sainte-Catherine, H3T 1C5, Montreal, QC, Canada aut NATIONALLICENCE 700 1- Perron Michel ECOBES, Recherche et transfert, Cegep de Jonquière, G7X 3W1, Jonquière, QC, Canada aut NATIONALLICENCE 700 1- Pike Bruce Département des sciences de la santé, Université du Québec à Chicoutimi, G7H 2B1, Chicoutimi, QC, Canada aut NATIONALLICENCE 700 1- Richer Louis Département des sciences de la santé, Université du Québec à Chicoutimi, G7H 2B1, Chicoutimi, QC, Canada aut NATIONALLICENCE 700 1- Veillette Suzanne ECOBES, Recherche et transfert, Cegep de Jonquière, G7X 3W1, Jonquière, QC, Canada aut NATIONALLICENCE 700 1- Pausova Zdenka School of Psychology, University of Nottingham, NG72RD, Nottingham, UK aut NATIONALLICENCE 700 1- Paus Tomáš Rotman Research Institute, University of Toronto, 3560 Bathurst Street, M6A 2E1, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3233-3244 1863-2653 220:6<3233 2015 220 429