caa a22 4500 606201521 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0861-2 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0861-2 Contralateral cerebello-thalamo-cortical pathways with prominent involvement of associative areas in humans in vivo [Elektronische Daten] [Fulvia Palesi, Jacques-Donald Tournier, Fernando Calamante, Nils Muhlert, Gloria Castellazzi, Declan Chard, Egidio D'Angelo, Claudia Wheeler-Kingshott] In addition to motor functions, it has become clear that in humans the cerebellum plays a significant role in cognition too, through connections with associative areas in the cerebral cortex. Classical anatomy indicates that neo-cerebellar regions are connected with the contralateral cerebral cortex through the dentate nucleus, superior cerebellar peduncle, red nucleus and ventrolateral anterior nucleus of the thalamus. The anatomical existence of these connections has been demonstrated using virus retrograde transport techniques in monkeys and rats ex vivo. In this study, using advanced diffusion MRI tractography we show that it is possible to calculate streamlines to reconstruct the pathway connecting the cerebellar cortex with contralateral cerebral cortex in humans in vivo. Corresponding areas of the cerebellar and cerebral cortex encompassed similar proportion (about 80%) of the tract, suggesting that the majority of streamlines passing through the superior cerebellar peduncle connect the cerebellar hemispheres through the ventrolateral thalamus with contralateral associative areas. This result demonstrates that this kind of tractography is a useful tool to map connections between the cerebellum and the cerebral cortex and moreover could be used to support specific theories about the abnormal communication along these pathways in cognitive dysfunctions in pathologies ranging from dyslexia to autism. The Author(s), 2014 Cerebral cortex nationallicence Cerebellum nationallicence Diffusion MRI nationallicence MRI tractography nationallicence Palesi Fulvia Department of Physics, University of Pavia, Via Bassi 6, 27100, Pavia, Italy aut Tournier Jacques-Donald The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, 3084, Heidelberg, VIC, Australia aut Calamante Fernando The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, 3084, Heidelberg, VIC, Australia aut Muhlert Nils Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut Castellazzi Gloria Brain Connectivity Center, C. Mondino National Neurological Institute, Via Mondino 2, 27100, Pavia, Italy aut Chard Declan Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut D'Angelo Egidio Brain Connectivity Center, C. Mondino National Neurological Institute, Via Mondino 2, 27100, Pavia, Italy aut Wheeler-Kingshott Claudia Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3369-3384 1863-2653 220:6<3369 2015 220 429 https://doi.org/10.1007/s00429-014-0861-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0861-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Palesi Fulvia Department of Physics, University of Pavia, Via Bassi 6, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Tournier Jacques-Donald The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, 3084, Heidelberg, VIC, Australia aut NATIONALLICENCE 700 1- Calamante Fernando The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, 245 Burgundy Street, 3084, Heidelberg, VIC, Australia aut NATIONALLICENCE 700 1- Muhlert Nils Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Castellazzi Gloria Brain Connectivity Center, C. Mondino National Neurological Institute, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Chard Declan Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- D'Angelo Egidio Brain Connectivity Center, C. Mondino National Neurological Institute, Via Mondino 2, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Wheeler-Kingshott Claudia Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3369-3384 1863-2653 220:6<3369 2015 220 429