caa a22 4500 60620153X CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0863-0 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0863-0 Role of fronto-striatal tract and frontal aslant tract in movement and speech: an axonal mapping study [Elektronische Daten] [Masashi Kinoshita, Nicolas de Champfleur, Jeremy Deverdun, Sylvie Moritz-Gasser, Guillaume Herbet, Hugues Duffau] Despite a better understanding of their anatomy, the functional role of frontal pathways, i.e., the fronto-striatal tract (FST) and frontal aslant tract (FAT), remains obscure. We studied 19 patients who underwent awake surgery for a frontal glioma (14 left, 5 right) by performing intraoperative electrical mapping of both fascicles during motor and language tasks. Furthermore, we evaluated the relationship between these tracts and the eventual onset of transient postoperative disorders. We also performed post-surgical tract-specific measurements on probabilistic tractography. All patients but one experienced intraoperative inhibition of movement and/or speech during subcortical electrostimulation. On postoperative tractography, the subcortical distribution of stimulated sites corresponded to the spatial course of the FST and/or FAT. Furthermore, we found a significant correlation between postoperative worsening and distances between these tracts and resection cavity. A resection close to the (right or left) FST was correlated with transitory motor initiation disorders (p=0.026), while a resection close to the left FAT was associated with transient speech initiation disorders (p=0.003). Moreover, the measurements of average distances between resection cavity and left FAT showed a positive correlation with verbal fluency in both semantic (p=0.019) and phonemic scores (p=0.017), while average distances between surgical cavity and left FST showed a positive correlation with verbal fluency scores in both semantic (p=0.0003) and phonemic modalities (p=0.037). We suggest that FST and FAT would cooperatively play a role in self-initiated movement and speech, as a part of "negative motor network” involving the pre-supplementary motor area, left inferior frontal gyrus and caudate nucleus. Springer-Verlag Berlin Heidelberg, 2014 Frontal aslant tract nationallicence Fronto-striatal tract nationallicence Functional electrical mapping nationallicence Speech initiation nationallicence Tractography imaging nationallicence FAT : Frontal aslant tract nationallicence IQR : Inter quantile range nationallicence FST : Fronto-striatal tract nationallicence SMA : Supplementary motor area nationallicence WHO : World Health Organization nationallicence VOI : Volume of interest nationallicence Kinoshita Masashi Department of Neurosurgery, Kanazawa University, Kanazawa, Japan aut de Champfleur Nicolas Department of Neuroradiology, Hôpital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France aut Deverdun Jeremy Department of Neuroradiology, Hôpital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France aut Moritz-Gasser Sylvie Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut Herbet Guillaume Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut Duffau Hugues Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3399-3412 1863-2653 220:6<3399 2015 220 429 https://doi.org/10.1007/s00429-014-0863-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0863-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kinoshita Masashi Department of Neurosurgery, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- de Champfleur Nicolas Department of Neuroradiology, Hôpital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France aut NATIONALLICENCE 700 1- Deverdun Jeremy Department of Neuroradiology, Hôpital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France aut NATIONALLICENCE 700 1- Moritz-Gasser Sylvie Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut NATIONALLICENCE 700 1- Herbet Guillaume Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut NATIONALLICENCE 700 1- Duffau Hugues Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3399-3412 1863-2653 220:6<3399 2015 220 429