caa a22 4500 606201548 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0854-1 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0854-1 Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3Tesla [Elektronische Daten] [Kathryn Rhindress, Toshikazu Ikuta, Robin Wellington, Anil Malhotra, Philip Szeszko] Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1-3). MR images were obtained in the coronal plane using a standard 3D spoiled gradient sequence acquired on a GE 3T scanner through the whole head in approximately 10min. The average ICC for inter-rater reliability across right and left volumetric regions-of-interest was 0.85 (range 0.71-0.98, median 0.86) and the average ICC for intra-rater reliability was 0.92 (range 0.66-0.99, median 0.97). The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70-0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82-0.90, median 0.85). An investigation of hippocampal asymmetry revealed significantly greater right compared to left hemisphere volumes in the anterior segment of CA1-3 and in the subiculum. Springer-Verlag Berlin Heidelberg, 2014 Magnetic resonance imaging nationallicence Hippocampus nationallicence Subregion nationallicence 3Tesla nationallicence Delineation criteria nationallicence Rhindress Kathryn Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA aut Ikuta Toshikazu Department of Communication Sciences and Disorders, University of Mississippi, Oxford, MS, USA aut Wellington Robin Department of Psychology, St. John's University, Queens, NY, USA aut Malhotra Anil Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA aut Szeszko Philip Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3259-3272 1863-2653 220:6<3259 2015 220 429 https://doi.org/10.1007/s00429-014-0854-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0854-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rhindress Kathryn Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA aut NATIONALLICENCE 700 1- Ikuta Toshikazu Department of Communication Sciences and Disorders, University of Mississippi, Oxford, MS, USA aut NATIONALLICENCE 700 1- Wellington Robin Department of Psychology, St. John's University, Queens, NY, USA aut NATIONALLICENCE 700 1- Malhotra Anil Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA aut NATIONALLICENCE 700 1- Szeszko Philip Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3259-3272 1863-2653 220:6<3259 2015 220 429