caa a22 4500 606201556 CHVBK 20210128100948.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0873-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0873-y Striatal GABA-MRS predicts response inhibition performance and its cortical electrophysiological correlates [Elektronische Daten] [Clara Quetscher, Ali Yildiz, Shalmali Dharmadhikari, Benjamin Glaubitz, Tobias Schmidt-Wilcke, Ulrike Dydak, Christian Beste] Response inhibition processes are important for performance monitoring and are mediated via a network constituted by different cortical areas and basal ganglia nuclei. At the basal ganglia level, striatal GABAergic medium spiny neurons are known to be important for response selection, but the importance of the striatal GABAergic system for response inhibition processes remains elusive. Using a novel combination of behavior al, EEG and magnetic resonance spectroscopy (MRS) data, we examine the relevance of the striatal GABAergic system for response inhibition processes. The study shows that striatal GABA levels modulate the efficacy of response inhibition processes. Higher striatal GABA levels were related to better response inhibition performance. We show that striatal GABA modulate specific subprocesses of response inhibition related to pre-motor inhibitory processes through the modulation of neuronal synchronization processes. To our knowledge, this is the first study providing direct evidence for the relevance of the striatal GABAergic system for response inhibition functions and their cortical electrophysiological correlates in humans. Springer-Verlag Berlin Heidelberg, 2014 Striatum nationallicence GABA nationallicence Response inhibition nationallicence EEG nationallicence Magnetic resonance spectroscopy nationallicence Quetscher Clara Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut Yildiz Ali Institute for Cognitive Neuroscience, Biopsychology, Ruhr-Universität Bochum, Bochum, Germany aut Dharmadhikari Shalmali School of Health Sciences, Purdue University, West Lafayette, USA aut Glaubitz Benjamin Department of Neurology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany aut Schmidt-Wilcke Tobias Department of Neurology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany aut Dydak Ulrike School of Health Sciences, Purdue University, West Lafayette, USA aut Beste Christian Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3555-3564 1863-2653 220:6<3555 2015 220 429 https://doi.org/10.1007/s00429-014-0873-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0873-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quetscher Clara Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut NATIONALLICENCE 700 1- Yildiz Ali Institute for Cognitive Neuroscience, Biopsychology, Ruhr-Universität Bochum, Bochum, Germany aut NATIONALLICENCE 700 1- Dharmadhikari Shalmali School of Health Sciences, Purdue University, West Lafayette, USA aut NATIONALLICENCE 700 1- Glaubitz Benjamin Department of Neurology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany aut NATIONALLICENCE 700 1- Schmidt-Wilcke Tobias Department of Neurology, Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Universität Bochum, Bochum, Germany aut NATIONALLICENCE 700 1- Dydak Ulrike School of Health Sciences, Purdue University, West Lafayette, USA aut NATIONALLICENCE 700 1- Beste Christian Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3555-3564 1863-2653 220:6<3555 2015 220 429