caa a22 4500 606201572 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0887-5 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0887-5 Maturation of preterm newborn brains: a fMRI-DTI study of auditory processing of linguistic stimuli and white matter development [Elektronische Daten] [Cristina Baldoli, Elisa Scola, Pasquale Della Rosa, Silvia Pontesilli, Roberta Longaretti, Antonella Poloniato, Roberta Scotti, Valeria Blasi, Sara Cirillo, Antonella Iadanza, Rosanna Rovelli, Graziano Barera, Paola Scifo] To evaluate brain development longitudinally in premature infants without abnormalities as compared to healthy full-term newborns, we assessed fMRI brain activity patterns in response to linguistic stimuli and white matter structural development focusing on language-related fibres. A total sample of 29 preterm newborns and 26 at term control newborns underwent both fMRI and DTI. Griffiths test was performed at 6months of corrected age to assess development. Auditory fMRI data were analysed in 17 preterm newborns at three time points [34, 41 and 44weeks of post menstrual age (wPMA)] and in 15 controls, at term. Analysis showed a distinctive pattern of cortical activation in preterm newborns up to 29 wPMA moving from early prevalent left temporal and supramarginal area activation in the preterm period, to a bilateral temporal and frontoopercular activation in the at term equivalent period and to a more fine-grained left pattern of activity at 44 wPMA. At term controls showed instead greater bilateral posterior thalamic activation. The different pattern of brain activity associated to preterm newborns mirrors their white matter maturation delay in peripheral regions of the fibres and thalamo-cortical radiations in subcortical areas of both hemispheres, pointing to different transient thalamo-cortical development due to prematurity. Evidence for functional thalamic activation and more mature subcortical tracts, including thalamic radiations, may represent the substantial gap between preterm and at term infants. The transition between bilateral temporal activations at term age and leftward activations at 44weeks of PMA is correlated to better neuropsychological results in Griffiths test. Springer-Verlag Berlin Heidelberg, 2014 Preterm nationallicence Brain nationallicence fMRI nationallicence Development nationallicence Subplate nationallicence DTI nationallicence Baldoli Cristina Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Scola Elisa Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Della Rosa Pasquale Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Milan, Italy aut Pontesilli Silvia Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Longaretti Roberta Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Poloniato Antonella Division of Neonatology, Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy aut Scotti Roberta Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Blasi Valeria Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Cirillo Sara Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Iadanza Antonella Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut Rovelli Rosanna Division of Neonatology, Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy aut Barera Graziano Division of Neonatology, Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy aut Scifo Paola CERMAC, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3733-3751 1863-2653 220:6<3733 2015 220 429 https://doi.org/10.1007/s00429-014-0887-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0887-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baldoli Cristina Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Scola Elisa Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Della Rosa Pasquale Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Milan, Italy aut NATIONALLICENCE 700 1- Pontesilli Silvia Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Longaretti Roberta Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Poloniato Antonella Division of Neonatology, Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Scotti Roberta Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Blasi Valeria Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Cirillo Sara Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Iadanza Antonella Department of Neuroradiology, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Rovelli Rosanna Division of Neonatology, Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Barera Graziano Division of Neonatology, Department of Pediatrics, San Raffaele Scientific Institute, Milan, Italy aut NATIONALLICENCE 700 1- Scifo Paola CERMAC, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3733-3751 1863-2653 220:6<3733 2015 220 429