caa a22 4500 606201580 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0853-2 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0853-2 Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset [Elektronische Daten] [Tetsuya Sasaki, Hirosato Aoi, Tomofumi Oga, Ichiro Fujita, Noritaka Ichinohe] In the primate cerebral cortex, dendritic spines rapidly increase in number after birth up to infancy or mid-childhood, and then decrease towards adulthood. Abnormalities in these processes accompany several psychiatric disorders. In this study, we examined developmental changes of basal dendrites and spines of layer III pyramidal cells in the medial prefrontal cortex (mPFC) of the common marmoset. The mPFC consists of several areas with distinct features in layer organization, histochemistry, connections, and, in humans, vulnerability to psychiatric disorders. We selected three areas for examination: granular dorsomedial prefrontal (area 8B/9), dysgranular ventromedial prefrontal (area 14r), and agranular anterior cingulate (area 24) cortices. Dendritic field areas, lengths, number of branching points, and total spine number reached a peak at 2-3 postnatal months in all three areas. However, the profiles of spine formation and pruning differed across the three areas with different degrees of granularity; the amount of spine loss from the peak to adulthood was less in areas 24 (33%) and 14r (29%) than in area 8B/9 (43%). Disturbance of this modest spine pruning in the less granular cortical areas may lead to an excessive loss of spines reported for areas 24 and 14r of schizophrenic patients. Springer-Verlag Berlin Heidelberg, 2014 Basal dendrite nationallicence Spine pruning nationallicence Granularity nationallicence Cortical development nationallicence Schizophrenia nationallicence Sasaki Tetsuya Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut Aoi Hirosato Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut Oga Tomofumi Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut Fujita Ichiro Graduate School of Frontier Biosciences, Osaka University, 1-4 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Ichinohe Noritaka Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3245-3258 1863-2653 220:6<3245 2015 220 429 https://doi.org/10.1007/s00429-014-0853-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0853-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sasaki Tetsuya Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoi Hirosato Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut NATIONALLICENCE 700 1- Oga Tomofumi Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujita Ichiro Graduate School of Frontier Biosciences, Osaka University, 1-4 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Ichinohe Noritaka Department of Ultrastructural Research, National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4-1-1 Ogawa-Higashi, 187-8502, Kodaira, Tokyo, Japan aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3245-3258 1863-2653 220:6<3245 2015 220 429