caa a22 4500 606201599 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0878-6 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0878-6 TMS stimulation over the inferior parietal cortex disrupts prospective sense of agency [Elektronische Daten] [Valérian Chambon, James Moore, Patrick Haggard] Sense of agency refers to the feeling of controlling an external event through one's own action. On one influential view, sense of agency is inferred after an action, by "retrospectively” comparing actual effects of actions against their intended effects. However, it has been recently shown that earlier processes, linked to action selection, may also contribute to sense of agency, in advance of the action itself, and independently of action effects. The inferior parietal cortex (IPC) may underpin this "prospective” contribution to agency, by monitoring signals relating to fluency of action selection in dorsolateral prefrontal cortex (DLPFC). Here, we combined transcranial stimulation (TMS) with subliminal priming of action selection to investigate the causal role of these regions in the prospective coding of agency. In a first experiment, we showed that TMS over left IPC at the time of action selection disrupts perceived control over subsequent effects of action. In a second experiment, we exploited the temporal specificity of single-pulse TMS to pinpoint the exact timing of IPC contribution to sense of agency. We replicated the reduction in perceived control at the point of action selection, while observing no effect of TMS-induced disruption of IPC at the time of action outcomes. Springer-Verlag Berlin Heidelberg, 2014 Action selection nationallicence Agency nationallicence Inferior parietal cortex nationallicence Dorsolateral prefrontal cortex nationallicence Single-pulse TMS nationallicence Chambon Valérian Laboratoire de Neurosciences Cognitives, Institut Jean Nicod, Ecole Normale Supérieure, CNRS, 29, rue d'Ulm, 75005, Paris, France aut Moore James Department of Psychology, Goldsmiths College, University of London, SE14 6NW, London, UK aut Haggard Patrick Institute of Cognitive Neuroscience, University College London, WC1N 3AR, London, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3627-3639 1863-2653 220:6<3627 2015 220 429 https://doi.org/10.1007/s00429-014-0878-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0878-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chambon Valérian Laboratoire de Neurosciences Cognitives, Institut Jean Nicod, Ecole Normale Supérieure, CNRS, 29, rue d'Ulm, 75005, Paris, France aut NATIONALLICENCE 700 1- Moore James Department of Psychology, Goldsmiths College, University of London, SE14 6NW, London, UK aut NATIONALLICENCE 700 1- Haggard Patrick Institute of Cognitive Neuroscience, University College London, WC1N 3AR, London, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3627-3639 1863-2653 220:6<3627 2015 220 429