caa a22 4500 606201602 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0844-3 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0844-3 Frontal glutamate and reward processing in adolescence and adulthood [Elektronische Daten] [Tobias Gleich, Robert Lorenz, Lydia Pöhland, Diana Raufelder, Lorenz Deserno, Anne Beck, Andreas Heinz, Simone Kühn, Jürgen Gallinat] The fronto-limbic network interaction, driven by glutamatergic and dopaminergic neurotransmission, represents a core mechanism of motivated behavior and personality traits. Reward seeking behavior undergoes tremendous changes in adolescence paralleled by neurobiological changes of this network including the prefrontal cortex, striatum and amygdala. Since fronto-limbic dysfunctions also underlie major psychiatric diseases beginning in adolescence, this investigation focuses on network characteristics separating adolescents from adults. To investigate differences in network interactions, the brain reward system activity (slot machine task) together with frontal glutamate concentration (anterior cingulate cortex, ACC) was measured in 28 adolescents and 26 adults employing functional magnetic resonance imaging and magnetic resonance spectroscopy, respectively. An inverse coupling of glutamate concentrations in the ACC and activation of the ventral striatum was observed in adolescents. Further, amygdala response in adolescents was negatively correlated with the personality trait impulsivity. For adults, no significant associations of network components or correlations with impulsivity were found. The inverse association between frontal glutamate concentration and striatal activation in adolescents is in line with the triadic model of motivated behavior stressing the important role of frontal top-down inhibition on limbic structures. Our data identified glutamate as the mediating neurotransmitter of this inhibitory process and demonstrates the relevance of glutamate on the reward system and related behavioral traits like impulsivity. This fronto-limbic coupling may represent a vulnerability factor for psychiatric disorders starting in adolescence but not in adulthood. Springer-Verlag Berlin Heidelberg, 2014 Reward processing nationallicence Aging nationallicence Adolescence nationallicence fMRI nationallicence Ventral striatum nationallicence Glutamate nationallicence MRS nationallicence Gleich Tobias Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Lorenz Robert Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Pöhland Lydia Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Raufelder Diana Department of Educational Science and Psychology, Methods and Evaluation, Freie Universität Berlin, Berlin, Germany aut Deserno Lorenz Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Beck Anne Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Heinz Andreas Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Kühn Simone Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Gallinat Jürgen Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3087-3099 1863-2653 220:6<3087 2015 220 429 https://doi.org/10.1007/s00429-014-0844-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0844-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gleich Tobias Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Lorenz Robert Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Pöhland Lydia Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Raufelder Diana Department of Educational Science and Psychology, Methods and Evaluation, Freie Universität Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Deserno Lorenz Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Beck Anne Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Heinz Andreas Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Kühn Simone Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 700 1- Gallinat Jürgen Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3087-3099 1863-2653 220:6<3087 2015 220 429