caa a22 4500 606201637 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0855-0 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0855-0 Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates [Elektronische Daten] [Judith Mylius, Max Happel, Alexander Gorkin, Ying Huang, Henning Scheich, Michael Brosch] Motivated by the increasing evidence that auditory cortex is under control of dopaminergic cell structures of the ventral midbrain, we studied how the ventral tegmental area and substantia nigra affect neuronal activity in auditory cortex. We electrically stimulated 567 deep brain sites in total within and in the vicinity of the two dopaminergic ventral midbrain structures and at the same time, recorded local field potentials and neuronal discharges in cortex. In experiments conducted on three awake macaque monkeys, we found that electrical stimulation of the dopaminergic ventral midbrain resulted in short-latency (~35ms) phasic activations in all cortical layers of auditory cortex. We were also able to demonstrate similar activations in secondary somatosensory cortex and superior temporal polysensory cortex. The electrically evoked responses in these parts of sensory cortex were similar to those previously described for prefrontal cortex. Moreover, these phasic responses could be reversibly altered by the dopamine D1-receptor antagonist SCH23390 for several tens of minutes. Thus, we speculate that the dopaminergic ventral midbrain exerts a temporally precise, phasic influence on sensory cortex using fast-acting non-dopaminergic transmitters and that their effects are modulated by dopamine on a longer timescale. Our findings suggest that some of the information carried by the neuronal discharges in the dopaminergic ventral midbrain, such as the motivational value or the motivational salience, is transmitted to auditory cortex and other parts of sensory cortex. The mesocortical pathway may thus contribute to the representation of non-auditory events in the auditory cortex and to its associative functions. Springer-Verlag Berlin Heidelberg, 2014 Deep brain stimulation nationallicence Primate nationallicence Auditory cortex nationallicence Glutamate corelease nationallicence Ventral tegmental area nationallicence Mylius Judith Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut Happel Max Department Systems Physiology of Learning, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut Gorkin Alexander Institute of Psychology, Russian Academy of Sciences, Yaroslavskaya Street 13, 129366, Moscow, Russia aut Huang Ying Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut Scheich Henning Emeritus Group Lifelong Learning, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut Brosch Michael Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3273-3294 1863-2653 220:6<3273 2015 220 429 https://doi.org/10.1007/s00429-014-0855-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0855-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mylius Judith Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut NATIONALLICENCE 700 1- Happel Max Department Systems Physiology of Learning, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut NATIONALLICENCE 700 1- Gorkin Alexander Institute of Psychology, Russian Academy of Sciences, Yaroslavskaya Street 13, 129366, Moscow, Russia aut NATIONALLICENCE 700 1- Huang Ying Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut NATIONALLICENCE 700 1- Scheich Henning Emeritus Group Lifelong Learning, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut NATIONALLICENCE 700 1- Brosch Michael Special Laboratory Primate Neurobiology, Leibniz Institute for Neurobiology, Brenneckestraße 6, 39118, Magdeburg, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3273-3294 1863-2653 220:6<3273 2015 220 429