caa a22 4500 606201653 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0866-x doi (NATIONALLICENCE)springer-10.1007/s00429-014-0866-x The disorganized visual cortex in reelin-deficient mice is functional and allows for enhanced plasticity [Elektronische Daten] [Justyna Pielecka-Fortuna, Robin Wagener, Ann-Kristin Martens, Bianka Goetze, Karl-Friedrich Schmidt, Jochen Staiger, Siegrid Löwel] A hallmark of neocortical circuits is the segregation of processing streams into six distinct layers. The importance of this layered organization for cortical processing and plasticity is little understood. We investigated the structure, function and plasticity of primary visual cortex (V1) of adult mice deficient for the glycoprotein reelin and their wild-type littermates. In V1 of rl−/− mice, cells with different laminar fates are present at all cortical depths. Surprisingly, the (vertically) disorganized cortex maintains a precise retinotopic (horizontal) organization. Rl−/− mice have normal basic visual capabilities, but are compromised in more challenging perceptual tasks, such as orientation discrimination. Additionally, rl−/− animals learn and memorize a visual task as well as their wild-type littermates. Interestingly, reelin deficiency enhances visual cortical plasticity: juvenile-like ocular dominance plasticity is preserved into late adulthood. The present data offer an important insight into the capabilities of a disorganized cortical system to maintain basic functional properties. The Author(s), 2014 Primary visual cortex nationallicence Cortical plasticity nationallicence Reeler nationallicence Laminar fate nationallicence Thalamocortical nationallicence Pielecka-Fortuna Justyna Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut Wagener Robin Institute for Neuroanatomy, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Kreuzbergring 36, 37075, Göttingen, Germany aut Martens Ann-Kristin Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut Goetze Bianka Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut Schmidt Karl-Friedrich Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut Staiger Jochen Institute for Neuroanatomy, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Kreuzbergring 36, 37075, Göttingen, Germany aut Löwel Siegrid Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3449-3467 1863-2653 220:6<3449 2015 220 429 https://doi.org/10.1007/s00429-014-0866-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0866-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pielecka-Fortuna Justyna Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Wagener Robin Institute for Neuroanatomy, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Kreuzbergring 36, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Martens Ann-Kristin Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Goetze Bianka Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Schmidt Karl-Friedrich Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Staiger Jochen Institute for Neuroanatomy, Universitätsmedizin Göttingen, Georg-August-Universität Göttingen, Kreuzbergring 36, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Löwel Siegrid Department of Systems Neuroscience, Bernstein Fokus Neurotechnologie, Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie, Georg-August-Universität Göttingen, Von-Siebold-Str. 6, 37075, Göttingen, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3449-3467 1863-2653 220:6<3449 2015 220 429