caa a22 4500 606201726 CHVBK 20210128100949.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0877-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0877-7 Endogenous-cue prospective memory involving incremental updating of working memory: an fMRI study [Elektronische Daten] [Harsha Halahalli, John John, Ammu Lukose, Sanjeev Jain, Bindu Kutty] Introduction: Prospective memory paradigms are conventionally classified on the basis of event-, time-, or activity-based intention retrieval. In the vast majority of such paradigms, intention retrieval is provoked by some kind of external event. However, prospective memory retrieval cues that prompt intention retrieval in everyday life are commonly endogenous, i.e., linked to a specific imagined retrieval context. We describe herein a novel prospective memory paradigm wherein the endogenous cue is generated by incremental updating of working memory, and investigated the hemodynamic correlates of this task. Methods: Eighteen healthy adult volunteers underwent functional magnetic resonance imaging while they performed a prospective memory task where the delayed intention was triggered by an endogenous cue generated by incremental updating of working memory. Working memory and ongoing task control conditions were also administered. Results: The ‘endogenous-cue prospective memory condition' with incremental working memory updating was associated with maximum activations in the right rostral prefrontal cortex, and additional activations in the brain regions that constitute the bilateral fronto-parietal network, central and dorsal salience networks as well as cerebellum. In the working memory control condition, maximal activations were noted in the left dorsal anterior insula. Conclusions: Activation of the bilateral dorsalanterior insula, a component of the central salience network, was found to be unique to this ‘endogenous-cue prospective memory task' in comparison to previously reported exogenous- and endogenous-cue prospective memory tasks without incremental working memory updating. Thus, the findings of the present study highlightthe important role played by the dorsal anterior insulain incremental working memory updating that is integral to our endogenous-cue prospective memory task. Springer-Verlag Berlin Heidelberg, 2014 Endogenous-cue prospective memory nationallicence Dorsal anterior insula nationallicence Salience network nationallicence Rostral prefrontal cortex nationallicence Topological false discovery rate nationallicence Language-independent prospective memory task nationallicence Halahalli Harsha Multimodal Brain Image Analysis Laboratory (MBIAL), Neurobiology Research Center (NRC), Dharmaram P.O., Hosur Road, PB No. 2900, 560 029, Bangalore, Karnataka, India aut John John Multimodal Brain Image Analysis Laboratory (MBIAL), Neurobiology Research Center (NRC), Dharmaram P.O., Hosur Road, PB No. 2900, 560 029, Bangalore, Karnataka, India aut Lukose Ammu Multimodal Brain Image Analysis Laboratory (MBIAL), Neurobiology Research Center (NRC), Dharmaram P.O., Hosur Road, PB No. 2900, 560 029, Bangalore, Karnataka, India aut Jain Sanjeev Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), 560029, Bangalore, India aut Kutty Bindu Department of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), 560029, Bangalore, India aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3611-3626 1863-2653 220:6<3611 2015 220 429 https://doi.org/10.1007/s00429-014-0877-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0877-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Halahalli Harsha Multimodal Brain Image Analysis Laboratory (MBIAL), Neurobiology Research Center (NRC), Dharmaram P.O., Hosur Road, PB No. 2900, 560 029, Bangalore, Karnataka, India aut NATIONALLICENCE 700 1- John John Multimodal Brain Image Analysis Laboratory (MBIAL), Neurobiology Research Center (NRC), Dharmaram P.O., Hosur Road, PB No. 2900, 560 029, Bangalore, Karnataka, India aut NATIONALLICENCE 700 1- Lukose Ammu Multimodal Brain Image Analysis Laboratory (MBIAL), Neurobiology Research Center (NRC), Dharmaram P.O., Hosur Road, PB No. 2900, 560 029, Bangalore, Karnataka, India aut NATIONALLICENCE 700 1- Jain Sanjeev Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), 560029, Bangalore, India aut NATIONALLICENCE 700 1- Kutty Bindu Department of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), 560029, Bangalore, India aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3611-3626 1863-2653 220:6<3611 2015 220 429