caa a22 4500 606201823 CHVBK 20210128100950.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0881-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0881-y Multi-parametric evaluation of the white matter maturation [Elektronische Daten] [S. Kulikova, L. Hertz-Pannier, G. Dehaene-Lambertz, A. Buzmakov, C. Poupon, J. Dubois] In vivo evaluation of the brain white matter maturation is still a challenging task with no existing gold standards. In this article we propose an original approach to evaluate the early maturation of the white matter bundles, which is based on comparison of infant and adult groups using the Mahalanobis distance computed from four complementary MRI parameters: quantitative qT1 and qT2 relaxation times, longitudinal λ║ and transverse λ⊥ diffusivities from diffusion tensor imaging. Such multi-parametric approach is expected to better describe maturational asynchrony than conventional univariate approaches because it takes into account complementary dependencies of the parameters on different maturational processes, notably the decrease in water content and the myelination. Our approach was tested on 17 healthy infants (aged 3- to 21-week old) for 18 different bundles. It finely confirmed maturational asynchrony across the bundles: the spino-thalamic tract, the optic radiations, the cortico-spinal tract and the fornix have the most advanced maturation, while the superior longitudinal and arcuate fasciculi, the anterior limb of the internal capsule and the external capsule have the most delayed maturation. Furthermore, this approach was more reliable than univariate approaches as it revealed more maturational relationships between the bundles and did not violate a priori assumptions on the temporal order of the bundle maturation. Mahalanobis distances decreased exponentially with age in all bundles, with the only difference between them explained by different onsets of maturation. Estimation of these relative delays confirmed that the most dramatic changes occur during the first post-natal year. The Author(s), 2014 Mahalanobis distance nationallicence White matter nationallicence Brain development nationallicence Bundles nationallicence Infants nationallicence T1 and T2 relaxometry nationallicence Diffusion tensor Imaging DTI nationallicence Kulikova S. UMR 1129 NeuroSpin/UNIACT, INSERM-CEA, Gif-sur-Yvette, France aut Hertz-Pannier L. UMR 1129 NeuroSpin/UNIACT, INSERM-CEA, Gif-sur-Yvette, France aut Dehaene-Lambertz G. UMR 992 NeuroSpin/UNICOG INSERM-CEA, Gif-sur-Yvette, France aut Buzmakov A. LORIA, CNRS-Inria Nancy Grand Est-Université de Lorraine, Nancy, France aut Poupon C. NeuroSpin/UNIRS CEA-Saclay, Gif-sur-Yvette, France aut Dubois J. UMR 992 NeuroSpin/UNICOG INSERM-CEA, Gif-sur-Yvette, France aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3657-3672 1863-2653 220:6<3657 2015 220 429 https://doi.org/10.1007/s00429-014-0881-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0881-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kulikova S. UMR 1129 NeuroSpin/UNIACT, INSERM-CEA, Gif-sur-Yvette, France aut NATIONALLICENCE 700 1- Hertz-Pannier L. UMR 1129 NeuroSpin/UNIACT, INSERM-CEA, Gif-sur-Yvette, France aut NATIONALLICENCE 700 1- Dehaene-Lambertz G. UMR 992 NeuroSpin/UNICOG INSERM-CEA, Gif-sur-Yvette, France aut NATIONALLICENCE 700 1- Buzmakov A. LORIA, CNRS-Inria Nancy Grand Est-Université de Lorraine, Nancy, France aut NATIONALLICENCE 700 1- Poupon C. NeuroSpin/UNIRS CEA-Saclay, Gif-sur-Yvette, France aut NATIONALLICENCE 700 1- Dubois J. UMR 992 NeuroSpin/UNICOG INSERM-CEA, Gif-sur-Yvette, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3657-3672 1863-2653 220:6<3657 2015 220 429