caa a22 4500 606201831 CHVBK 20210128100950.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0845-2 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0845-2 Working memory training impacts the mean diffusivity in the dopaminergic system [Elektronische Daten] [Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Hiroshi Hashizume, Atsushi Sekiguchi, Yuka Kotozaki, Seishu Nakagawa, Carlos Miyauchi, Yuko Sassa, Ryuta Kawashima] Dopaminergic transmission plays a critical role in working memory (WM). Mean diffusivity (MD) is a sensitive and unique neuroimaging tool for detecting microstructural differences particularly in the areas of the dopaminergic system. Despite previous investigation of the effects of WM training (WMT) on dopamine receptor binding potentials, the effects of WMT on MD remain unknown. In this study, we investigated these effects in young adult subjects who either underwent WMT or received no intervention for 4weeks. Before and after the intervention or no-intervention periods, subjects underwent scanning sessions in diffusion-weighted imaging to measure MD. Compared with no intervention, WMT resulted in an increase in MD in the bilateral caudate, right putamen, left dorsolateral prefrontal cortex (DLPFC), right anterior cingulate cortex (ACC), right substantia nigra, and ventral tegmental area. Furthermore, the increase in performance on WMT tasks was significantly positively correlated with the mean increase in MD in the clusters of the left DLPFC and of the right ACC. These results suggest that WMT caused microstructural changes in the regions of the dopaminergic system in a way that is usually interpreted as a reduction in neural components. The Author(s), 2014 Working memory nationallicence Training nationallicence Plasticity nationallicence Mean diffusivity nationallicence Dopamine nationallicence MRI nationallicence Diffusion-weighted imaging nationallicence Takeuchi Hikaru Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut Taki Yasuyuki Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut Nouchi Rui Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan aut Hashizume Hiroshi Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut Sekiguchi Atsushi Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan aut Kotozaki Yuka Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan aut Nakagawa Seishu Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan aut Miyauchi Carlos Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan aut Sassa Yuko Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut Kawashima Ryuta Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3101-3111 1863-2653 220:6<3101 2015 220 429 https://doi.org/10.1007/s00429-014-0845-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0845-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takeuchi Hikaru Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Taki Yasuyuki Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Nouchi Rui Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Hashizume Hiroshi Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Sekiguchi Atsushi Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Kotozaki Yuka Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Nakagawa Seishu Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Miyauchi Carlos Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan aut NATIONALLICENCE 700 1- Sassa Yuko Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 700 1- Kawashima Ryuta Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, 980-8575, Sendai, Japan aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3101-3111 1863-2653 220:6<3101 2015 220 429