caa a22 4500 60620184X CHVBK 20210128100950.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0868-8 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0868-8 Prefronto-subcortical imbalance characterizes poor decision-making: neurochemical and neural functional evidences in rats [Elektronische Daten] [Aurélie Fitoussi, Catherine Le Moine, Philippe De Deurwaerdère, Matéo Laqui, Marion Rivalan, Martine Cador, Françoise Dellu-Hagedorn] A major challenge of decision-making research in recent years has been to develop models of poor decision-making to identify its neural bases. Toward this goal, we developed a Rat Gambling Task that discerns good and poor decision-makers in a complex and conflicting situation such as the human Iowa Gambling Task. Nothing is known about the role of the monoaminergic modulatory systems in shaping these phenotypes. Moreover, functional and temporal contributions of brain areas during poor compared to good decision-making remains elusive. Good and poor decision-makers were identified in the Rat Gambling Task. We investigated neurobiological correlates of decision-making capacities in (1) dopamine and serotonin turnovers using post-mortem tissue measurements, (2) the neural circuits differentially recruited during decision-making within the prefronto-subcortical network using cellular Fos immunodetection. Imbalance in monoamine metabolism was revealed in poor decision-makers, i.e. a higher infralimbic vs. lower amygdala serotonergic metabolism. Moreover, good decision-making recruited a wide prefronto-subcortical network but once good choices had been made, a disengagement of key prefrontal areas (insular and infralimbic cortices notably) and the amygdala was observed. By contrast, poor decision-making was associated with a strikingly low recruitment of the prefronto-subcortical network, together with sustained amygdala activity. Our results identify two complementary neurobiological substrates characterizing poor decision-makers: imbalanced monoaminergic systems at rest, congruent with their previously identified complex behavioral phenotype, and an aberrant low recruitment of key brain areas for executive functions and affective valence during the process of decision-making. These biomarkers could sustain vulnerability to developing poor decision-making related disorders. Springer-Verlag Berlin Heidelberg, 2014 Decision-making nationallicence Gambling task nationallicence Inter-individual differences nationallicence Fos neuronal marker nationallicence Dopamine nationallicence Serotonin nationallicence Rodent model nationallicence Fitoussi Aurélie University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut Le Moine Catherine University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut De Deurwaerdère Philippe University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut Laqui Matéo University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut Rivalan Marion University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut Cador Martine University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut Dellu-Hagedorn Françoise University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3485-3496 1863-2653 220:6<3485 2015 220 429 https://doi.org/10.1007/s00429-014-0868-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0868-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fitoussi Aurélie University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Le Moine Catherine University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- De Deurwaerdère Philippe University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Laqui Matéo University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Rivalan Marion University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Cador Martine University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 700 1- Dellu-Hagedorn Françoise University of Bordeaux, INCIA, CNRS UMR 5287, PB. 31, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3485-3496 1863-2653 220:6<3485 2015 220 429