caa a22 4500 606201866 CHVBK 20210128100950.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-014-0858-x doi (NATIONALLICENCE)springer-10.1007/s00429-014-0858-x Resting-state connectivity and functional specialization in human medial parieto-occipital cortex [Elektronische Daten] [Annalisa Tosoni, Sabrina Pitzalis, Giorgia Committeri, Patrizia Fattori, Claudio Galletti, Gaspare Galati] According to recent models of visuo-spatial processing, the medial parieto-occipital cortex is a crucial node of the dorsal visual stream. Evidence from neurophysiological studies in monkeys has indicated that the parieto-occipital sulcus (POS) contains three functionally and cytoarchitectonically distinct areas: the visual area V6 in the fundus of the POS, and the visuo-motor areas V6Av and V6Ad in a progressively dorsal and anterior location with respect to V6. Besides different topographical organization, cytoarchitectonics, and functional properties, these three monkey areas can also be distinguished based on their patterns of cortico-cortical connections. Thanks to wide-field retinotopic mapping, areas V6 and V6Av have been also mapped in the human brain. Here, using a combined approach of resting-state functional connectivity and task-evoked activity by fMRI, we identified a new region in the anterior POS showing a pattern of functional properties and cortical connections that suggests a homology with the monkey area V6Ad. In addition, we observed distinct patterns of cortical connections associated with the human V6 and V6Av which are remarkably consistent with those showed by the anatomical tracing studies in the corresponding monkey areas. Consistent with recent models on visuo-spatial processing, our findings demonstrate a gradient of functional specialization and cortical connections within the human POS, with more posterior regions primarily dedicated to the analysis of visual attributes useful for spatial navigation and more anterior regions primarily dedicated to analyses of spatial information relevant for goal-directed action. Springer-Verlag Berlin Heidelberg, 2014 Functional connectivity MRI nationallicence Visual area V6 nationallicence Visuo-motor area V6A nationallicence V6Av-V6Ad nationallicence Tosoni Annalisa Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University, Via dei Vestini, 33, 66013, Chieti, Italy aut Pitzalis Sabrina Department of Motor, Human and Health Sciences, University of Rome "Foro Italico”, Rome, Italy aut Committeri Giorgia Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University, Via dei Vestini, 33, 66013, Chieti, Italy aut Fattori Patrizia Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy aut Galletti Claudio Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy aut Galati Gaspare Laboratory of Neuropsychology, Santa Lucia Foundation, Rome, Italy aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3307-3321 1863-2653 220:6<3307 2015 220 429 https://doi.org/10.1007/s00429-014-0858-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0858-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tosoni Annalisa Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University, Via dei Vestini, 33, 66013, Chieti, Italy aut NATIONALLICENCE 700 1- Pitzalis Sabrina Department of Motor, Human and Health Sciences, University of Rome "Foro Italico”, Rome, Italy aut NATIONALLICENCE 700 1- Committeri Giorgia Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio University, Via dei Vestini, 33, 66013, Chieti, Italy aut NATIONALLICENCE 700 1- Fattori Patrizia Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Galletti Claudio Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Galati Gaspare Laboratory of Neuropsychology, Santa Lucia Foundation, Rome, Italy aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3307-3321 1863-2653 220:6<3307 2015 220 429