caa a22 4500 606201874 CHVBK 20210128100950.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00429-015-1047-2 doi (NATIONALLICENCE)springer-10.1007/s00429-015-1047-2 Topographic organization of the human and non-human primate subthalamic nucleus [Elektronische Daten] [Anneke Alkemade, Alfons Schnitzler, Birte Forstmann] Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is used to relieve motor symptoms of Parkinson's disease. A tripartite system of STN subdivisions serving motoric, associative, and limbic functions was proposed, mainly based on tracing studies, which are limited by low numbers of observations. The evidence is compelling and raises the question as to what extent these functional zones are anatomically segregated. The majority of studies indicate that there is anatomical overlap between STN functional zones. Using ultrahigh-resolution magnetic resonance imaging techniques it is now possible to visualize the STN with high spatial resolution, and it is feasible that in the near future stereotactic guided placement of electrical stimulators aided by high-resolution imaging will allow for more specific stimulation of the STN. The neuroanatomical and functional makeup of these subdivisions and their level of overlap would benefit from clarification before serving as surgical targets. We discuss histological and imaging studies, as well as clinical observations and electrophysiological recordings in DBS patients. These studies provide evidence for a topographical organization within the STN, although it remains unclear to what extent functionally and anatomically distinct subdivisions overlap. The Author(s), 2015 Basal ganglia nationallicence Parkinson's disease nationallicence Deep brain stimulation nationallicence Decision making nationallicence Alkemade Anneke Cognitive Science Center Amsterdam, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS, Amsterdam, The Netherlands aut Schnitzler Alfons Department of Neurology, Medical Faculty, Center for Movement Disorders and Neuromodulation, Heinrich-Heine University, Düsseldorf, Germany aut Forstmann Birte Cognitive Science Center Amsterdam, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS, Amsterdam, The Netherlands aut Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3075-3086 1863-2653 220:6<3075 2015 220 429 https://doi.org/10.1007/s00429-015-1047-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-015-1047-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alkemade Anneke Cognitive Science Center Amsterdam, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Schnitzler Alfons Department of Neurology, Medical Faculty, Center for Movement Disorders and Neuromodulation, Heinrich-Heine University, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Forstmann Birte Cognitive Science Center Amsterdam, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/6(2015-11-01), 3075-3086 1863-2653 220:6<3075 2015 220 429