caa a22 4500 606201998 CHVBK 20210128100951.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0723-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0723-y Individual differences in regional prefrontal gray matter morphometry and fractional anisotropy are associated with different constructs of executive function [Elektronische Daten] [H. Smolker, B. Depue, A. Reineberg, J. Orr, M. Banich] Although the relationship between structural differences within the prefrontal cortex (PFC) and executive function (EF) has been widely explored in cognitively impaired populations, little is known about this relationship in healthy young adults. Using optimized voxel-based morphometry (VBM), surface-based morphometry (SBM), and fractional anisotropy (FA) we determined the association between regional PFC grey matter (GM) morphometry and white matter tract diffusivity with performance on tasks that tap different aspects of EF as drawn from Miyake et al.'s three-factor model of EF. Reductions in both GM volume (VBM) and cortical folding (SBM) in the ventromedial PFC (vmPFC), ventrolateral PFC (vlPFC), and dorsolateral PFC (dlPFC) predicted better common EF, shifting-specific, and updating-specific performance, respectively. Despite capturing different components of GM morphometry, voxel- and surface-based findings were highly related, exhibiting regionally overlapping relationships with EF. Increased white matter FA in fiber tracts that connect the vmPFC and vlPFC with posterior regions of the brain also predicted better commonEF and shifting-specific performance, respectively. These results suggest that the neural mechanisms supporting distinct aspects of EF may differentially rely on distinct regions of the PFC, and at least in healthy young adults, are influenced by regional morphometry of the PFC and the FA of major white matter tracts that connect the PFC with posterior cortical and subcortical regions. Springer-Verlag Berlin Heidelberg, 2014 MRI nationallicence Anatomy nationallicence PFC nationallicence Executive function nationallicence Grey matter nationallicence White matter nationallicence Smolker H. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut Depue B. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut Reineberg A. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut Orr J. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut Banich M. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1291-1306 1863-2653 220:3<1291 2015 220 429 https://doi.org/10.1007/s00429-014-0723-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0723-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smolker H. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut NATIONALLICENCE 700 1- Depue B. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut NATIONALLICENCE 700 1- Reineberg A. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut NATIONALLICENCE 700 1- Orr J. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut NATIONALLICENCE 700 1- Banich M. The Institute of Cognitive Science, University of Colorado, Boulder, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1291-1306 1863-2653 220:3<1291 2015 220 429