caa a22 4500 606202013 CHVBK 20210128100951.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0721-0 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0721-0 Four-month enriched environment prevents myelinated fiber loss in the white matter during normal aging of male rats [Elektronische Daten] [Shu Yang, Wei Lu, De-shan Zhou, Yong Tang] White matter degenerates with normal aging and accordingly results in declines in multiple brain functions. Previous neuroimaging studies have implied that the white matter is plastic by experiences and contributory to the experience-dependent recovery of brain functions. However, it is not clear how and how far enriched environment (EE) plays a role in the white matter remodeling. Male rats exhibit earlier and severer age-related damages in the white matter and its myelinated fibers than female rats; therefore, in this current study, 24 middle-aged (14-month-old) and 24 old-aged (24-month-old) male SD rats were randomly assigned to an EEor standard environment (SE)for 4months prior to Morris water maze tests. Five rats from each group were then randomly sampled for stereological assessment of the white matter. Results revealed that EE could somewhat induce improvement of spatial learning and significantlyincrease the white matter volume, the myelinated fiber volume and the myelinated fiber length during normal aging. The EE-induced improvement of spatial learning ability was significantly correlated with the EE-induced increase of the white matter and its myelinated fibers. We suggested that exposure to an EE could delay the progress of age-related changes in the white matter and the effect could extend to old age. Springer-Verlag Berlin Heidelberg, 2014 Aging nationallicence Enriched environment nationallicence Myelinated fiber nationallicence Stereology nationallicence White matter nationallicence Yang Shu Department of Histology and Embryology, Chongqing Medical University, 400016, Chongqing, People's Republic of China aut Lu Wei Department of Pediatrics, Navy General Hospital, 100069, Beijing, People's Republic of China aut Zhou De-shan Department of Histology and Embryology, Capital Medical University, 100069, Beijing, People's Republic of China aut Tang Yong Department of Histology and Embryology, Chongqing Medical University, 400016, Chongqing, People's Republic of China aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1263-1272 1863-2653 220:3<1263 2015 220 429 https://doi.org/10.1007/s00429-014-0721-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0721-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Shu Department of Histology and Embryology, Chongqing Medical University, 400016, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Lu Wei Department of Pediatrics, Navy General Hospital, 100069, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhou De-shan Department of Histology and Embryology, Capital Medical University, 100069, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Tang Yong Department of Histology and Embryology, Chongqing Medical University, 400016, Chongqing, People's Republic of China aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1263-1272 1863-2653 220:3<1263 2015 220 429