caa a22 4500 606202080 CHVBK 20210128100951.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0725-9 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0725-9 Midbrain volume predicts fMRI and ERP measures of reward reactivity [Elektronische Daten] [Joshua Carlson, Dan Foti, Eddie Harmon-Jones, Greg Proudfit] Ventral striatal activation measured with functional magnetic resonance imaging (fMRI) and feedback negativity amplitude measured with event-related potentials (ERPs) are each enhanced during reward processing. Recent research has found that these two neural measures of reward processing are also related to one another, such that increases in ventral striatal activity are accompanied by increases in the amplitude of the feedback negativity. Although there is a long history of research implicating the midbrain dopamine system in reward processing, there has been little research into the possibility that structural variability in the midbrain may be linked to functional variability in reward reactivity. Here, we used structural MRI to measure midbrain volumes in addition to fMRI and ERP measures of functional neural reactivity to rewards in a simple gambling task. The results suggest that as midbrain volumes increase, fMRI reward reactivity in the ventral striatum and medial prefrontal cortex also increases. A similar relationship exists between midbrain structure and the amplitude of the feedback negativity; further, this relationship is mediated specifically by activity in the ventral striatum. These data demonstrate convergence between neuroanatomical, hemodynamic, and electrophysiological measures. Thus, structural variability in the midbrain relates to variability in fMRI and ERP measures of functional reward reactivity, which may play a critical role in reward-related psychopathologies and the treatment of these disorders. Springer-Verlag Berlin Heidelberg, 2014 Reward nationallicence Striatum nationallicence Volume nationallicence Morphology nationallicence Feedback negativity nationallicence VBM nationallicence Carlson Joshua Department of Psychology, Northern Michigan University, 49855, Marquette, MI, USA aut Foti Dan Department of Psychology, Purdue University, West Lafayette, IN, USA aut Harmon-Jones Eddie School of Psychology, The University of New South Wales, Sydney, Australia aut Proudfit Greg Department of Psychology, Stony Brook University, Stony Brook, NY, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1861-1866 1863-2653 220:3<1861 2015 220 429 https://doi.org/10.1007/s00429-014-0725-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0725-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carlson Joshua Department of Psychology, Northern Michigan University, 49855, Marquette, MI, USA aut NATIONALLICENCE 700 1- Foti Dan Department of Psychology, Purdue University, West Lafayette, IN, USA aut NATIONALLICENCE 700 1- Harmon-Jones Eddie School of Psychology, The University of New South Wales, Sydney, Australia aut NATIONALLICENCE 700 1- Proudfit Greg Department of Psychology, Stony Brook University, Stony Brook, NY, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1861-1866 1863-2653 220:3<1861 2015 220 429