caa a22 4500 606202099 CHVBK 20210128100951.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0751-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0751-7 Asymmetry, connectivity, and segmentation of the arcuate fascicle in the human brain [Elektronische Daten] [Juan Fernández-Miranda, Yibao Wang, Sudhir Pathak, Lucia Stefaneau, Timothy Verstynen, Fang-Cheng Yeh] The structure and function of the arcuate fascicle is still controversial. The goal of this study was to investigate the asymmetry, connectivity, and segmentation patterns of the arcuate fascicle. We employed diffusion spectrum imaging reconstructed by generalized q-sampling and we applied both a subject-specific approach (10 subjects) and a template approach (q-space diffeomorphic reconstruction of 30 subjects). We complemented our imaging investigation with fiber microdissection of five post-mortem human brains. Our results confirmed the highly leftward asymmetry of the arcuate fascicle. In the template, the left arcuate had a volume twice as large as the right one, and the left superior temporal gyrus provided five times more volume of fibers than its counterpart. We identified four cortical frontal areas of termination: pars opercularis, pars triangularis, ventral precentral gyrus, and caudal middle frontal gyrus. We found clear asymmetry of the frontal terminations at pars opercularis and ventral precentral gyrus. The analysis of patterns of connectivity revealed the existence of a strong structural segmentation in the left arcuate, but not in the right one. The left arcuate fascicle is formed by an inner or ventral pathway, which interconnects pars opercularis with superior and rostral middle temporal gyri; and an outer or dorsal pathway, which interconnects ventral precentral and caudal middle frontal gyri with caudal middle and inferior temporal gyri. The fiber microdissection results provided further support to our tractography studies. We propose the existence of primary and supplementary language pathways within the dominant arcuate fascicle with potentially distinct functional and lesional features. Springer-Verlag Berlin Heidelberg, 2014 Arcuate fascicle nationallicence Diffusion spectrum imaging nationallicence Tractography nationallicence Language nationallicence Fiber dissection nationallicence AAL : Automated anatomical labeling nationallicence AF : Arcuate fascicle nationallicence BA : Brodmann area nationallicence CORID : Committee for oversight research involving dead nationallicence DSI : Diffusion spectrum imaging nationallicence DTI : Diffusion tensor imaging nationallicence EPI : Echo planar imaging nationallicence fMRI : Functional MRI nationallicence FoV : Field of view nationallicence GQI : Generalized q-sampling imaging nationallicence ITG : Inferior temporal gyrus nationallicence MdLF : Middle longitudinal fascicle nationallicence MTG : Middle temporal gyrus nationallicence ODF : Orientation distribution function nationallicence QA : Quantitative anisotropy nationallicence ROI : Region of interest nationallicence SLF : Superior longitudinal fascicle nationallicence STG : Superior temporal gyrus nationallicence TR : Repetition time nationallicence Fernández-Miranda Juan Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Suite B-400, 15213, Pittsburgh, PA, USA aut Wang Yibao Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Suite B-400, 15213, Pittsburgh, PA, USA aut Pathak Sudhir Learning Research and Development Center, University of Pittsburgh, Pittsburgh, PA, USA aut Stefaneau Lucia Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Suite B-400, 15213, Pittsburgh, PA, USA aut Verstynen Timothy Department of Bioengineering, Carnegie Mellon University, Pittsburgh, PA, USA aut Yeh Fang-Cheng Department of Bioengineering, Carnegie Mellon University, Pittsburgh, PA, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1665-1680 1863-2653 220:3<1665 2015 220 429 https://doi.org/10.1007/s00429-014-0751-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0751-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-Miranda Juan Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Suite B-400, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Wang Yibao Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Suite B-400, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Pathak Sudhir Learning Research and Development Center, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Stefaneau Lucia Department of Neurological Surgery, University of Pittsburgh Medical Center, 200 Lothrop St, Suite B-400, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Verstynen Timothy Department of Bioengineering, Carnegie Mellon University, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Yeh Fang-Cheng Department of Bioengineering, Carnegie Mellon University, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1665-1680 1863-2653 220:3<1665 2015 220 429