caa a22 4500 606202137 CHVBK 20210128100951.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0737-5 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0737-5 Implications of p75NTR for dentate gyrus morphology and hippocampus-related behavior revisited [Elektronische Daten] [M. Dokter, R. Busch, R. Poser, M. Vogt, V. von Bohlen und Halbach, P. Gass, K. Unsicker, O. von Bohlen und Halbach] The pan-neurotrophin receptor p75NTR is expressed in the adult brain in a discrete pattern. Although numerous studies have addressed its implications for hippocampal functions, the generated sets of data are surprisingly conflicting. We have therefore set out to re-investigate the impact of a deletion of the full-length p75NTR receptor on several parameters of the dentate gyrus (DG), including neurogenesis and hippocampus-related behavior by using p75NTRExIII knockout mice. Moreover, we investigated further parameters of the DG (cholinergic innervation, dendritic spines). In addition, we analyzed on the morphological level the impact of aging by comparing adult and aged p75NTRExIII mice and their age-matched littermates. Adult (4-6months old), but not aged (20months old), p75NTRExIII knockout mice display an enhanced volume of the DG. However, adult neurogenesis within the adult DG was unaffected in both adult and aged p75NTRExIII knockout mice. We could further demonstrate that the change in the volume of the DG was accompanied by an increased cholinergic innervation and increased spine densities of granule cells in adult, but not aged p75NTR deficient mice. These morphological changes in the adult p75NTR deficient mice were accompanied by specific alterations in their behavior, including altered behavior in the Morris water maze test, indicating impairments in spatial memory retention. Springer-Verlag Berlin Heidelberg, 2014 Neurotrophin nationallicence p75NTR nationallicence Adult neurogenesis nationallicence Dendritic spine nationallicence Morris water maze nationallicence Aging nationallicence Dokter M. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut Busch R. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut Poser R. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut Vogt M. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany aut von Bohlen und Halbach V. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut Gass P. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany aut Unsicker K. Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr.17, 79104, Freiburg, Germany aut von Bohlen und Halbach O. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1449-1462 1863-2653 220:3<1449 2015 220 429 https://doi.org/10.1007/s00429-014-0737-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0737-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dokter M. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut NATIONALLICENCE 700 1- Busch R. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut NATIONALLICENCE 700 1- Poser R. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut NATIONALLICENCE 700 1- Vogt M. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- von Bohlen und Halbach V. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut NATIONALLICENCE 700 1- Gass P. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Unsicker K. Department of Molecular Embryology, Institute of Anatomy and Cell Biology, University of Freiburg, Albertstr.17, 79104, Freiburg, Germany aut NATIONALLICENCE 700 1- von Bohlen und Halbach O. Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1449-1462 1863-2653 220:3<1449 2015 220 429