caa a22 4500 606202145 CHVBK 20210128100951.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0748-2 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0748-2 Direct diffusion-based parcellation of the human thalamus [Elektronische Daten] [Vinod Kumar, Sarah Mang, Wolfgang Grodd] To assess stable anatomical features of the human thalamus, an unbiased diffusion tensor parcellation approach was used to segment thalamic substructures with similar spatial orientation. We determined localization, size and individual variations of 21 thalamic clusters in a group of 63 healthy human subjects (32 males/31 females). The laterality differences accounted for ±6% and gender differences for ±4% of the thalamic volume. Consecutively, five stable clusters in the anterior, medial, lateral and posterior thalamus were selected, which were common to 90% of all subjects and contained at least 10 voxels. These clusters could be assigned to the anteroventral nucleus (AN) group, the mediodorsal (MD) nucleus, the medial pulvinar (PuM), and the lateral nuclei group. The subcortical and cortical connectivity of these clusters revealed that: (1) the oblique cranio-caudal-oriented fibers of the AN cluster mainly connect to limbic structures, (2) the numerous dorso-frontal-oriented fibers of MD mainly project to the prefrontal cortex and the medial temporal lobe, (3) the fibers of the PuM running in parallel with the x-axis project to medio-occipital and medio-temporal areas and connect visual areas with the hippocampus and amygdala and via intrathalamic pathways with medio-frontal areas, and (4) the oblique caudo-cranial fibers of the two lateral clusters located anteriorly in the motor and posteriorly in the sensory thalamus are routing sensory-motor information from the brain stem via the internal capsule to pre- and peri-central regions of the cortex. Springer-Verlag Berlin Heidelberg, 2014 Thalamus nationallicence Anatomy nationallicence Diffusion tensor imaging nationallicence Laterality nationallicence Gender nationallicence Connectivity nationallicence AC : Anterior commissure nationallicence Acc : Nucleus accumbens nationallicence AD : Anterodorsal nucleus nationallicence AM : Anteromedial nucleus nationallicence Amy : Amygdala nationallicence AN : Anterior cluster nationallicence AV : Anteroventral group nationallicence BS : Brainstem nationallicence Cau : Caudate nucleus nationallicence CoG : Center of gravity nationallicence DDO : Dominant diffusion orientations nationallicence Den : Dentate nucleus nationallicence DTI : Diffusion tensor imaging nationallicence EPI : Echo planar imaging nationallicence Hip : Hippocampus nationallicence LA : Lateral-anterior cluster nationallicence LD : Lateral dorsal group nationallicence LP : Lateral-posterior cluster nationallicence MD : Mediodorsal nucleus nationallicence MED : Medial cluster nationallicence MRI : Magnetic resonance imaging nationallicence Pal : Pallidum nationallicence PC : Posterior commissure nationallicence PO : Posterior cluster nationallicence PuM : Medial pulvinar nationallicence Put : Putamen nationallicence Red : Red nucleus nationallicence SD : Standard deviation nationallicence T : Tesla nationallicence TE : Echo time nationallicence TR : Repetition time nationallicence VA : Ventral anterior nationallicence VLa : Ventral lateral anterior nationallicence VLp : Ventral lateral posterior nationallicence VM : Ventral medial nationallicence VP : Ventral posterior complex nationallicence VPI : Ventral posterior inferior nucleus nationallicence VPL : Ventral posterolateral nationallicence VPM : Ventral posteromedial nationallicence Kumar Vinod Department of Psychiatry, Psychotherapy and Psychosomatics, JARA-Translational Brain Medicine, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Pauwelstr. 30, 52074, Aachen, Germany aut Mang Sarah Software Development for Integrated Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany aut Grodd Wolfgang Department of Psychiatry, Psychotherapy and Psychosomatics, JARA-Translational Brain Medicine, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Pauwelstr. 30, 52074, Aachen, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1619-1635 1863-2653 220:3<1619 2015 220 429 https://doi.org/10.1007/s00429-014-0748-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0748-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kumar Vinod Department of Psychiatry, Psychotherapy and Psychosomatics, JARA-Translational Brain Medicine, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Pauwelstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Mang Sarah Software Development for Integrated Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Grodd Wolfgang Department of Psychiatry, Psychotherapy and Psychosomatics, JARA-Translational Brain Medicine, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Pauwelstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1619-1635 1863-2653 220:3<1619 2015 220 429