caa a22 4500 606202196 CHVBK 20210128100952.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0727-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0727-7 Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability [Elektronische Daten] [Vincenzo Fiore, Francesco Mannella, Marco Mirolli, Emanuele Latagliata, Alessandro Valzania, Simona Cabib, Raymond Dolan, Stefano Puglisi-Allegra, Gianluca Baldassarre] Abstract : Appraisal of a stressful situation and the possibility to control or avoid it is thought to involve frontal-cortical mechanisms. The precise mechanism underlying this appraisal and its translation into effective stress coping (the regulation of physiological and behavioural responses) are poorly understood. Here, we propose a computational model which involves tuning motivational arousal to the appraised stressing condition. The model provides a causal explanation of the shift from active to passive coping strategies, i.e. from a condition characterised by high motivational arousal, required to deal with a situation appraised as stressful, to a condition characterised by emotional and motivational withdrawal, required when the stressful situation is appraised as uncontrollable/unavoidable. The model is motivated by results acquired via microdialysis recordings in rats and highlights the presence of two competing circuits dominated by different areas of the ventromedial prefrontal cortex: these are shown having opposite effects on several subcortical areas, affecting dopamine outflow in the striatum, and therefore controlling motivation. We start by reviewing published data supporting structure and functioning of the neural model and present the computational model itself with its essential neural mechanisms. Finally, we show the results of a new experiment, involving the condition of repeated inescapable stress, which validate most of the model's predictions. The Author(s), 2014 Dopamine nationallicence Noradrenaline nationallicence Appraisal nationallicence Chronic stress nationallicence Animal model nationallicence Cortical control nationallicence Fiore Vincenzo Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, WC1N 3BG, London, UK aut Mannella Francesco Laboratory of Computational Embodied Neuroscience, Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (LOCEN-ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy aut Mirolli Marco Laboratory of Computational Embodied Neuroscience, Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (LOCEN-ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy aut Latagliata Emanuele Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut Valzania Alessandro Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut Cabib Simona Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut Dolan Raymond Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, WC1N 3BG, London, UK aut Puglisi-Allegra Stefano Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut Baldassarre Gianluca Laboratory of Computational Embodied Neuroscience, Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (LOCEN-ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1339-1353 1863-2653 220:3<1339 2015 220 429 https://doi.org/10.1007/s00429-014-0727-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0727-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiore Vincenzo Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Mannella Francesco Laboratory of Computational Embodied Neuroscience, Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (LOCEN-ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Mirolli Marco Laboratory of Computational Embodied Neuroscience, Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (LOCEN-ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Latagliata Emanuele Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut NATIONALLICENCE 700 1- Valzania Alessandro Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut NATIONALLICENCE 700 1- Cabib Simona Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut NATIONALLICENCE 700 1- Dolan Raymond Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Puglisi-Allegra Stefano Dipartimento di Psicologia and Centro Daniel Bovet, Sapienza Università di Roma, Via dei Marsi 78, 00183, Rome, Italy aut NATIONALLICENCE 700 1- Baldassarre Gianluca Laboratory of Computational Embodied Neuroscience, Istituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (LOCEN-ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1339-1353 1863-2653 220:3<1339 2015 220 429