caa a22 4500 606202234 CHVBK 20210128100952.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0746-4 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0746-4 Heschl's gyrification pattern is related to speech-listening hemispheric lateralization: FMRI investigation in 281 healthy volunteers [Elektronische Daten] [N. Tzourio-Mazoyer, D. Marie, L. Zago, G. Jobard, G. Perchey, G. Leroux, E. Mellet, M. Joliot, F. Crivello, L. Petit, B. Mazoyer] This study investigates the structure-function relationships between the anatomy of Heschl's gyri (HG) and speech hemispheric lateralization in 281 healthy volunteers (135 left-handers). Hemispheric lateralization indices (HFLIs) were calculated with Wilke's method from the activations obtained via functional magnetic resonance imaging while listening to lists of words (LIST). The mean HFLI during LIST was rightward asymmetrical, and left-handers displayed a trend toward decreased rightward asymmetry. The correlations between LIST BOLD contrast maps and individual HFLIs demonstrated that among the cortical areas showing significant asymmetry during LIST, only phonological regions explained HFLI variability. Significant positive correlations were present among the left HG, supramarginal gyri, and the anterior insula. Significant negative correlations occurred in the mid-part of the right superior temporal sulcus. Left HG had the largest functional activity during LIST and explained 10% of the HFLI variance. There was a strong anatomo-functional link in the HG: duplication was associated with a decrease in both the surface area of the anterior HG and HG functional activity. Participants with a single left HG exhibited leftward anatomical and functional asymmetry of HG, but participants with a left duplication lost either anatomical and/or functional leftward asymmetries. Finally, manual preference was related to HG anatomy, but not to HG functional asymmetries measured during LIST. The anatomical characteristics of left-handers (lower occurrence of right HG duplication and a smaller surface area of the right first HG) thus appeared to be unrelated to variations in speech lateralization with handedness. Springer-Verlag Berlin Heidelberg, 2014 Hemispheric specialization nationallicence Speech nationallicence Heschl's gyri nationallicence Handedness nationallicence Tzourio-Mazoyer N. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Marie D. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Zago L. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Jobard G. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Perchey G. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Leroux G. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Mellet E. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Joliot M. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Crivello F. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Petit L. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Mazoyer B. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1585-1599 1863-2653 220:3<1585 2015 220 429 https://doi.org/10.1007/s00429-014-0746-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0746-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tzourio-Mazoyer N. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Marie D. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Zago L. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Jobard G. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Perchey G. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Leroux G. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Mellet E. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Joliot M. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Crivello F. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Petit L. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 700 1- Mazoyer B. GIN, Groupe d'Imagerie Neurofonctionnelle UMR5296, Univ. Bordeaux, Bât. PQR, CHU Pellegrin, 33000, Bordeaux, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1585-1599 1863-2653 220:3<1585 2015 220 429