caa a22 4500 606202277 CHVBK 20210128100952.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0758-0 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0758-0 Aging and response conflict solution: behavioural and functional connectivity changes [Elektronische Daten] [Robert Langner, Edna Cieslik, Simone Behrwind, Christian Roski, Svenja Caspers, Katrin Amunts, Simon Eickhoff] Healthy aging has been found associated with lessefficient response conflict solution, but the cognitive and neural mechanisms have remained elusive. In a two-experiment study, we first examined the behavioural consequences of this putative age-related decline for conflicts induced by spatial stimulus-response incompatibility. We then used resting-state functional magnetic resonance imaging data from a large, independent sample of adults (n=399; 18-85years) to investigate age differences in functional connectivity between the nodes of a network previously found associated with incompatibility-induced response conflicts in the very same paradigm. As expected, overcoming interference from conflicting response tendencies took longer in older adults, even after accounting for potential mediator variables (general response speed and accuracy, motor speed, visuomotor coordination ability, and cognitive flexibility). Experiment 2 revealed selective age-related decreases in functional connectivity between bilateral anterior insula, pre-supplementary motor area, and right dorsolateral prefrontal cortex. Importantly, these age effects persisted after controlling for regional grey-matter atrophy assessed by voxel-based morphometry. Meta-analytic functional profiling using the BrainMap database showed these age-sensitive nodes to be more strongly linked to highly abstract cognition, as compared with the remaining network nodes, which were more strongly linked to action-related processing. These findings indicate changes in interregional coupling with age among task-relevant network nodes that are not specifically associated with conflict resolution per se. Rather, our behavioural and neural data jointly suggest that healthy aging is associated with difficulties in properly activating non-dominant but relevant task schemata necessary to exert efficient cognitive control over action. Springer-Verlag Berlin Heidelberg, 2014 Cognitive control nationallicence Adult age differences nationallicence Resting-state fMRI nationallicence Stimulus-response compatibility nationallicence BrainMap behavioural domains nationallicence Quantitative reverse inference nationallicence Langner Robert Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany aut Cieslik Edna Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany aut Behrwind Simone Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Roski Christian Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Caspers Svenja Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Amunts Katrin Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1739-1757 1863-2653 220:3<1739 2015 220 429 https://doi.org/10.1007/s00429-014-0758-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0758-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Langner Robert Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Cieslik Edna Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Behrwind Simone Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Roski Christian Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Caspers Svenja Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Amunts Katrin Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1739-1757 1863-2653 220:3<1739 2015 220 429