caa a22 4500 606202293 CHVBK 20210128100952.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0735-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0735-7 Evidence for divergent effects of neurodegeneration in Huntington's disease on attentional selection and neural plasticity: implications for excitotoxicity [Elektronische Daten] [Christian Beste, Ann-Kathrin Stock, Vanessa Ness, Rainer Hoffmann, Carsten Saft] It is generally assumed that neurodegeneration leads to declines in cognitive functions. However, there is evidence that neurodegenerative processes related to excitotoxicity can lead to paradoxical improvements in circumscribed cognitive functions, while at the same time other processes are compromised. An open question is how such paradoxical improvements reported in literature and declines usually associated with neurodegeneration relate to each other. Do paradoxical improvements only reflect a transient phenomenon, or do they intensify in the course of neurodegeneration? We examine this question using behavioral and neurophysiological (EEG) data in a human model of excitotoxic neurodegeneration (i.e., Huntington's disease, HD). The results show that attentional selection processes decline during pre-manifest disease progression. Importantly, the efficacy of protocols used to induce neural plasticity in processes underlying attentional selection processes also increases in course of ongoing neurodegeneration in pre-manifest HD. This was reflected in behavioral data and electrophysiological correlates of processes related to the allocation of attention. To conclude, our results suggest that circumscribed enhancements of specific cognitive functions are as much a result of the developmental process of neurodegeneration as the well-known detrimental effects. The results account for the divergent effects of neurodegenerative processes closely related to excitotoxicity on cognitive functions. Springer-Verlag Berlin Heidelberg, 2014 Neural plasticity nationallicence Neurodegeneration nationallicence Excitotoxicity nationallicence EEG nationallicence Huntington's disease nationallicence Attention nationallicence Beste Christian Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut Stock Ann-Kathrin Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut Ness Vanessa Institute for Cognitive Neuroscience, Biopsychology, Ruhr-University, Bochum, Germany aut Hoffmann Rainer Department of Neurology, Huntington Centre NRW, St. Josef Hospital, Ruhr-University, Bochum, Germany aut Saft Carsten Department of Neurology, Huntington Centre NRW, St. Josef Hospital, Ruhr-University, Bochum, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1437-1447 1863-2653 220:3<1437 2015 220 429 https://doi.org/10.1007/s00429-014-0735-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0735-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beste Christian Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut NATIONALLICENCE 700 1- Stock Ann-Kathrin Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany aut NATIONALLICENCE 700 1- Ness Vanessa Institute for Cognitive Neuroscience, Biopsychology, Ruhr-University, Bochum, Germany aut NATIONALLICENCE 700 1- Hoffmann Rainer Department of Neurology, Huntington Centre NRW, St. Josef Hospital, Ruhr-University, Bochum, Germany aut NATIONALLICENCE 700 1- Saft Carsten Department of Neurology, Huntington Centre NRW, St. Josef Hospital, Ruhr-University, Bochum, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1437-1447 1863-2653 220:3<1437 2015 220 429