caa a22 4500 606202307 CHVBK 20210128100952.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0744-6 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0744-6 Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer's disease: a coordinate-based meta-analysis [Elektronische Daten] [Nils Nellessen, Claudia Rottschy, Simon Eickhoff, Simon Ketteler, Hanna Kuhn, N. Shah, Jörg Schulz, Martina Reske, Kathrin Reetz] Episodic memory is typically affected during the course of Alzheimer's disease (AD). Due to the pronounced heterogeneity of functional neuroimaging studies on episodic memory impairments in mild cognitive impairment (MCI) and AD regarding their methodology and findings, we aimed to delineate consistent episodic memory-related brain activation patterns. We performed a systematic, quantitative, coordinate-based whole-brain activation likelihood estimation meta-analysis of 28 functional magnetic resonance imaging (fMRI) studies comprising 292 MCI and 102 AD patients contrasted to 409 age-matched control subjects. We included episodic encoding and/or retrieval phases, investigated the effects of group, verbal or image stimuli and correlated mean Mini-Mental-Status-Examination (MMSE) scores with the modelled activation estimates. MCI patients presented increased right hippocampal activation during memory encoding, decreased activation in the left hippocampus and fusiform gyrus during retrieval tasks, as well as attenuated activation in the right anterior insula/inferior frontal gyrus during verbal retrieval. In AD patients, however, stronger activation within the precuneus during encoding tasks was accompanied by attenuated right hippocampal activation during retrieval tasks. Low cognitive performance (MMSE scores) was associated with stronger activation of the precuneus and reduced activation of the right (para)hippocampus and anterior insula/inferior frontal gyrus. This meta-analysis provides evidence for a specific and probably disease stage-dependent brain activation pattern related to the pathognomonic AD characteristic of episodic memory loss. Springer-Verlag Berlin Heidelberg, 2014 Alzheimer's disease nationallicence Mild cognitive impairment nationallicence Episodic memory nationallicence Functional neuroimaging nationallicence Meta-analysis nationallicence Hippocampus nationallicence Nellessen Nils Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Rottschy Claudia Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany aut Eickhoff Simon Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany aut Ketteler Simon Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Kuhn Hanna Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Shah N. Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Schulz Jörg Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Reske Martina Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany aut Reetz Kathrin Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1555-1571 1863-2653 220:3<1555 2015 220 429 https://doi.org/10.1007/s00429-014-0744-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0744-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nellessen Nils Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Rottschy Claudia Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany aut NATIONALLICENCE 700 1- Eickhoff Simon Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany aut NATIONALLICENCE 700 1- Ketteler Simon Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Kuhn Hanna Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Shah N. Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Schulz Jörg Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Reske Martina Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428, Jülich, Germany aut NATIONALLICENCE 700 1- Reetz Kathrin Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1555-1571 1863-2653 220:3<1555 2015 220 429