caa a22 4500 606202315 CHVBK 20210128100952.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00429-014-0736-6 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0736-6 Sensitivity to self-administered cocaine within the lateral preoptic-rostral lateral hypothalamic continuum [Elektronische Daten] [David Barker, Brendan Striano, Kevin Coffey, David Root, Anthony Pawlak, Olivia Kim, Julianna Kulik, Anthony Fabbricatore, Mark West] The lateral preoptic-rostral lateral hypothalamic continuum (LPH) receives projections from the nucleus accumbens and is believed to be one route by which nucleus accumbens signaling affects motivated behaviors. While accumbens firing patterns are known to be modulated by fluctuating levels of cocaine, studies of the LPH's drug-related firing are absent from the literature. The present study sought to electrophysiologically test whether drug-related tonic and slow-phasic patterns exist in the firing of LPH neurons during a free-access cocaine self-administration task. Results demonstrated that a majority of neurons in the LPH exhibited changes in both tonic and slow-phasic firing rates during fluctuating drug levels. During the maintenance phase of self-administration, 69.6% of neurons exhibited at least a twofold change in tonic firing rate when compared to their pre-drug firing rates. Moreover, 54.4% of LPH neurons demonstrated slow-phasic patterns, specifically "progressive reversal” patterns, which have been shown to be related to pharmacological changes across the inter-infusion interval. Firing rate was correlated with calculated drug level in 58.7% of recorded cells. Typically, a negative correlation between drug level and firing rate was observed, with a majority of neurons showing decreases in firing during cocaine self-administration. A small percentage of LPH neurons also exhibited correlations between locomotor behavior and firing rate; however, correlations with drug level in these same neurons were always stronger. Thus, theweak relationships between LPH firing and locomotor behaviors during cocaine self-administration do not account for the observed changes in firing. Overall, these findings suggest that a proportion of LPH neurons are sensitive to fluctuations in cocaine concentration and may contribute to neural activity that controls drug taking. Springer-Verlag Berlin Heidelberg, 2014 Lateral preoptic nationallicence Rostral lateral hypothalamus nationallicence Addiction nationallicence Electrophysiology nationallicence Single unit nationallicence Barker David Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Striano Brendan Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Coffey Kevin Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Root David Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Pawlak Anthony Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Kim Olivia Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Kulik Julianna Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Fabbricatore Anthony Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut West Mark Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1841-1854 1863-2653 220:3<1841 2015 220 429 https://doi.org/10.1007/s00429-014-0736-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0736-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barker David Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Striano Brendan Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Coffey Kevin Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Root David Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Pawlak Anthony Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Kim Olivia Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Kulik Julianna Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Fabbricatore Anthony Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- West Mark Department of Psychology, Rutgers University, 152 Frelinghuysen Road, 08854, Piscataway, NJ, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/3(2015-05-01), 1841-1854 1863-2653 220:3<1841 2015 220 429