caa a22 4500 606202404 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0771-3 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0771-3 Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer's disease [Elektronische Daten] [Daniel Saiz-Sanchez, Carlos De la Rosa-Prieto, Isabel Ubeda-Banon, Alino Martinez-Marcos] Impaired olfaction has been described as an early symptom of Alzheimer's disease. Neuroanatomical changes underlying this deficit in the olfactory system are largely unknown. Interestingly, neuropathology begins in the transentorhinal cortex and extends to the neighboring limbic system and basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus and olfactory bulb. The human piriform cortex has been described as a crucial area in odor quality coding; disruption of this region mediates early olfactory deficits in Alzheimer's disease. Most neuropathological investigations have focused on the entorhinal cortex and hippocampus, whereas the piriform cortex has largely been neglected. This work aims to characterize the expression of the neuropathological amyloid-β peptide, tau protein and interneuron population markers (calretinin, parvalbumin and somatostatin) in the piriform cortex of ten Alzheimer-diagnosed (80.4±8.3years old) and five control (69.6±11.1) cases. Here, we examined the distribution of different interneuronal markers as well as co-localization of interneurons and pathological markers. Results indicated preferential vulnerability of somatostatin- (p=0.0001<α=0.05) and calretinin-positive (p=0.013<α=0.05) cells that colocalized with amyloid-β peptide, while the prevalence of parvalbumin-positive cells was increased (p=0.045<α=0.05) in the Alzheimer's cases. These data may help to reveal the neural basis of olfactory deficits linked to Alzheimer's disease as well as to characterize neuronal populations preferentially vulnerable to neuropathology in regions critically involved in early stages of the disease. Springer-Verlag Berlin Heidelberg, 2014 Amyloid-β nationallicence Human brain nationallicence Hyposmia nationallicence Tau nationallicence Piriform cortex nationallicence Somatostatin nationallicence Aβ : Amyloid beta nationallicence Ac : Accumbens nucleus nationallicence AD : Alzheimer's disease nationallicence AON : Anterior olfactory nucleus nationallicence API : Area piriformis insulae nationallicence CaBPs : Calcium binding proteins nationallicence Cd : Caudate nucleus nationallicence CSF : Cerebrospinal fluid nationallicence CR : Calretinin nationallicence Ent : Entorhinal cortex nationallicence lo : Lateral olfactory tract nationallicence LV : Lateral ventricle nationallicence NFTs : Neurofibrillary tangles nationallicence OB : Olfactory bulb nationallicence olf : Olfactory tract nationallicence OlfA : Olfactory area nationallicence ox : Optic chiasm nationallicence PAM : Periamygdaloid cortex nationallicence PACI : Periamygdalar claustrum nationallicence Pir : Piriform cortex nationallicence PirF : Piriform cortex (frontal lobe) nationallicence PirT : Piriform cortex (temporal lobe) nationallicence PD : Parkinson's disease nationallicence Pu : Putamen nationallicence PV : Parvalbumin nationallicence SOM : Somatostatin nationallicence SPs : Senile plaques nationallicence Tu : Olfactory tubercle nationallicence Saiz-Sanchez Daniel Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut De la Rosa-Prieto Carlos Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut Ubeda-Banon Isabel Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut Martinez-Marcos Alino Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2011-2025 1863-2653 220:4<2011 2015 220 429 https://doi.org/10.1007/s00429-014-0771-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0771-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saiz-Sanchez Daniel Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut NATIONALLICENCE 700 1- De la Rosa-Prieto Carlos Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Ubeda-Banon Isabel Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Martinez-Marcos Alino Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Avda. de Moledores s/n, 13071, Ciudad Real, Spain aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2011-2025 1863-2653 220:4<2011 2015 220 429