caa a22 4500 606202439 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0763-3 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0763-3 Characterizing longitudinal white matter development during early childhood [Elektronische Daten] [Douglas Dean III, Jonathan O'Muircheartaigh, Holly Dirks, Nicole Waskiewicz, Lindsay Walker, Ellen Doernberg, Irene Piryatinsky, Sean Deoni] Post-mortem studies have shown the maturation of the brain's myelinated white matter, crucial for efficient and coordinated brain communication, follows a nonlinear spatio-temporal pattern that corresponds with the onset and refinement of cognitive functions and behaviors. Unfortunately, investigation of myelination in vivo is challenging and, thus, little is known about the normative pattern of myelination, or its association with functional development. Using a novel quantitative magnetic resonance imaging technique sensitive to myelin we examined longitudinal white matter development in 108 typically developing children ranging in age from 2.5months to 5.5years. Using nonlinear mixed effects modeling, we provide the first in vivo longitudinal description of myelin water fraction development. Moreover, we show distinct male and female developmental patterns, and demonstrate significant relationships between myelin content and measures of cognitive function. These findings advance a new understanding of healthy brain development and provide a foundation from which to assess atypical development. The Author(s), 2014 Brain development nationallicence White matter development nationallicence Magnetic resonance imaging nationallicence Myelin water fraction nationallicence Dean III Douglas Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut O'Muircheartaigh Jonathan Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Dirks Holly Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Waskiewicz Nicole Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Walker Lindsay Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Doernberg Ellen Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Piryatinsky Irene Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Deoni Sean Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1921-1933 1863-2653 220:4<1921 2015 220 429 https://doi.org/10.1007/s00429-014-0763-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0763-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dean III Douglas Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- O'Muircheartaigh Jonathan Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Dirks Holly Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Waskiewicz Nicole Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Walker Lindsay Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Doernberg Ellen Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Piryatinsky Irene Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Deoni Sean Advanced Baby Imaging Laboratory, School of Engineering, Brown University, 02912, Providence, RI, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1921-1933 1863-2653 220:4<1921 2015 220 429