caa a22 4500 606202455 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0776-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0776-y Whole-scalp EEG mapping of somatosensory evoked potentials in macaque monkeys [Elektronische Daten] [Anne-Dominique Gindrat, Charles Quairiaux, Juliane Britz, Denis Brunet, Florian Lanz, Christoph Michel, Eric Rouiller] High-density scalp EEG recordings are widely used to study whole-brain neuronal networks in humans non-invasively. Here, we validate EEG mapping of somatosensory evoked potentials (SSEPs) in macaque monkeys (Macaca fascicularis) for the long-term investigation of large-scale neuronal networks and their reorganisation after lesions requiring a craniotomy. SSEPs were acquired from 33 scalp electrodes in five adult anaesthetized animals after electrical median or tibial nerve stimulation. SSEP scalp potential maps were identified by cluster analysis and identified in individual recordings. A distributed, linear inverse solution was used to estimate the intracortical sources of the scalp potentials. SSEPs were characterised by a sequence of components with unique scalp topographies. Source analysis confirmed that median nerve SSEP component maps were in accordance with the somatotopic organisation of the sensorimotor cortex. Most importantly, SSEP recordings were stable both intra- and interindividually. We aim to apply this method to the study of recovery and reorganisation of large-scale neuronal networks following a focal cortical lesion requiring a craniotomy. As a prerequisite, the present study demonstrated that a 300-mm2 unilateral craniotomy over the sensorimotor cortex necessary to induce a cortical lesion, followed by bone flap repositioning, suture and gap plugging with calcium phosphate cement, did not induce major distortions of the SSEPs. In conclusion, SSEPs can be successfully and reproducibly recorded from high-density EEG caps in macaque monkeys before and after a craniotomy, opening new possibilities for the long-term follow-up of the cortical reorganisation of large-scale networks in macaque monkeys after a cortical lesion. The Author(s), 2014 Craniotomy nationallicence Electrical neuroimaging nationallicence High-density EEG nationallicence LORETA inverse solution nationallicence Non-human primate nationallicence Sensorimotor cortex nationallicence CD : Current density nationallicence EEG : Electroencephalography nationallicence EPs : Evoked potentials nationallicence GA : Grand average nationallicence GEV : Global explained variance nationallicence GFP : Global field power nationallicence ICMS : Intracortical microstimulation nationallicence im : Intramuscular nationallicence iv : Intravenous nationallicence LORETA : Low-resolution electromagnetic tomography nationallicence LSI : Laser speckle imaging nationallicence M1 : Primary motor cortex nationallicence MRI : Magnetic resonance imaging nationallicence S1 : Primary somatosensory cortex nationallicence SC : Spatial correlation nationallicence sc : Subcutaneous nationallicence SD : Standard deviation nationallicence SE : Standard error nationallicence SSEPs : Somatosensory evoked potentials nationallicence Gindrat Anne-Dominique Domain of Physiology, Department of Medicine, Faculty of Sciences and Fribourg Center for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland aut Quairiaux Charles Department of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut Britz Juliane Functional Brain Mapping Laboratory, Departments of Clinical and Fundamental Neurosciences, University Medical School, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut Brunet Denis Functional Brain Mapping Laboratory, Departments of Clinical and Fundamental Neurosciences, University Medical School, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut Lanz Florian Domain of Physiology, Department of Medicine, Faculty of Sciences and Fribourg Center for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland aut Michel Christoph Functional Brain Mapping Laboratory, Departments of Clinical and Fundamental Neurosciences, University Medical School, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut Rouiller Eric Domain of Physiology, Department of Medicine, Faculty of Sciences and Fribourg Center for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2121-2142 1863-2653 220:4<2121 2015 220 429 https://doi.org/10.1007/s00429-014-0776-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0776-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gindrat Anne-Dominique Domain of Physiology, Department of Medicine, Faculty of Sciences and Fribourg Center for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland aut NATIONALLICENCE 700 1- Quairiaux Charles Department of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut NATIONALLICENCE 700 1- Britz Juliane Functional Brain Mapping Laboratory, Departments of Clinical and Fundamental Neurosciences, University Medical School, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut NATIONALLICENCE 700 1- Brunet Denis Functional Brain Mapping Laboratory, Departments of Clinical and Fundamental Neurosciences, University Medical School, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut NATIONALLICENCE 700 1- Lanz Florian Domain of Physiology, Department of Medicine, Faculty of Sciences and Fribourg Center for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland aut NATIONALLICENCE 700 1- Michel Christoph Functional Brain Mapping Laboratory, Departments of Clinical and Fundamental Neurosciences, University Medical School, Rue Michel-Servet 1, 1206, Geneva, Switzerland aut NATIONALLICENCE 700 1- Rouiller Eric Domain of Physiology, Department of Medicine, Faculty of Sciences and Fribourg Center for Cognition, University of Fribourg, Chemin du Musée 5, 1700, Fribourg, Switzerland aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2121-2142 1863-2653 220:4<2121 2015 220 429