caa a22 4500 606202471 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0773-1 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0773-1 The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study [Elektronische Daten] [Fabien Almairac, Guillaume Herbet, Sylvie Moritz-Gasser, Nicolas de Champfleur, Hugues Duffau] Consequential works in cognitive neuroscience have led to the formulation of an interactive dual-stream model of language processing: the dorsal stream may process the phonological aspects of language, whereas the ventral stream may process the semantic aspects of language. While it is well-accepted that the dorsal route is subserved by the arcuate fasciculus, the structural connectivity of the semantic ventral stream is a matter of dispute. Here we designed a longitudinal study to gain new insights into this central but controversial question. Thirty-one patients harboring a left diffuse low-grade glioma—a rare neurological condition that infiltrates preferentially white matter associative pathways—were assessed with a prototypical task of language (i.e. verbal fluency) before and after surgery. All were operated under local anesthesia with a cortical and subcortical brain mapping—enabling to identify and preserve eloquent structures for language. We performed voxel-based lesion-symptom (VLSM) analyses on pre- and postoperative behavioral data. Preoperatively, we found a significant relationship between semantic fluency scores and the white matter fibers shaping the ventro-lateral connectivity (P<0.05 corrected). The statistical map was found to substantially overlap with the spatial position of the inferior fronto-occipital fasciculus (IFOF) (37.7%). Furthermore, a negative correlation was observed between semantic fluency scores and the infiltration volumes in this fasciculus (r=−0.4, P=0.029). Postoperatively, VLSM analyses were inconclusive. Taken as a whole and when combined with the literature data, our findings strengthen the view that the IFOF plays an essential role in semantic processing and may subserve the direct ventral pathway of language. Springer-Verlag Berlin Heidelberg, 2014 Inferior fronto-occipital fasciculus nationallicence Language semantics nationallicence Brain mapping nationallicence Voxel-based lesion-symptom mapping nationallicence Diffuse low-grade glioma nationallicence Verbal fluency nationallicence Almairac Fabien Department of Neurosurgery, Hôpital Pasteur, University Hospital Center, 06000, Nice, France aut Herbet Guillaume Department of Neurosurgery, Hôpital Gui de Chauliac, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut Moritz-Gasser Sylvie Department of Neurosurgery, Hôpital Gui de Chauliac, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut de Champfleur Nicolas Department of Neuroradiology, Hôpital Gui de Chauliac, Montpellier University Medical Center, 34295, Montpellier, France aut Duffau Hugues Department of Neurosurgery, Hôpital Gui de Chauliac, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1983-1995 1863-2653 220:4<1983 2015 220 429 https://doi.org/10.1007/s00429-014-0773-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0773-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Almairac Fabien Department of Neurosurgery, Hôpital Pasteur, University Hospital Center, 06000, Nice, France aut NATIONALLICENCE 700 1- Herbet Guillaume Department of Neurosurgery, Hôpital Gui de Chauliac, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut NATIONALLICENCE 700 1- Moritz-Gasser Sylvie Department of Neurosurgery, Hôpital Gui de Chauliac, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut NATIONALLICENCE 700 1- de Champfleur Nicolas Department of Neuroradiology, Hôpital Gui de Chauliac, Montpellier University Medical Center, 34295, Montpellier, France aut NATIONALLICENCE 700 1- Duffau Hugues Department of Neurosurgery, Hôpital Gui de Chauliac, Montpellier University Medical Center, 80 Avenue Augustin Fliche, 34295, Montpellier, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1983-1995 1863-2653 220:4<1983 2015 220 429