caa a22 4500 606202544 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0791-z doi (NATIONALLICENCE)springer-10.1007/s00429-014-0791-z Neural networks related to dysfunctional face processing in autism spectrum disorder [Elektronische Daten] [Thomas Nickl-Jockschat, Claudia Rottschy, Johanna Thommes, Frank Schneider, Angela Laird, Peter Fox, Simon Eickhoff] One of the most consistent neuropsychological findings in autism spectrum disorders (ASD) is a reduced interest in and impaired processing of human faces. We conducted an activation likelihood estimation meta-analysis on 14 functional imaging studies on neural correlates of face processing enrolling a total of 164 ASD patients. Subsequently, normative whole-brain functional connectivity maps for the identified regions of significant convergence were computed for the task-independent (resting-state) and task-dependent (co-activations) state in healthy subjects. Quantitative functional decoding was performed by reference to the BrainMap database. Finally, we examined the overlap of the delineated network with the results of a previous meta-analysis on structural abnormalities in ASD as well as with brain regions involved in human action observation/imitation. We found a single cluster in the left fusiform gyrus showing significantly reduced activation during face processing in ASD across all studies. Both task-dependent and task-independent analyses indicated significant functional connectivity of this region with the temporo-occipital and lateral occipital cortex, the inferior frontal and parietal cortices, the thalamus and the amygdala. Quantitative reverse inference then indicated an association of these regions mainly with face processing, affective processing, and language-related tasks. Moreover, we found that the cortex in the region of right area V5 displaying structural changes in ASD patients showed consistent connectivity with the region showing aberrant responses in the context of face processing. Finally, this network was also implicated in the human action observation/imitation network. In summary, our findings thus suggest a functionally and structurally disturbed network of occipital regions related primarily to face (but potentially also language) processing, which interact with inferior frontal as well as limbic regions and may be the core of aberrant face processing and reduced interest in faces in ASD. Springer-Verlag Berlin Heidelberg, 2014 Autism nationallicence Autism spectrum disorders nationallicence Face processing nationallicence Fusiform face area nationallicence V5 nationallicence Meta-analysis nationallicence Nickl-Jockschat Thomas Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Rottschy Claudia Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Thommes Johanna Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Schneider Frank Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut Laird Angela Department of Physics, Florida International University, Miami, USA aut Fox Peter Research Imaging Institute, University of Texas Health Sciences Center, San Antonio, USA aut Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2355-2371 1863-2653 220:4<2355 2015 220 429 https://doi.org/10.1007/s00429-014-0791-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0791-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nickl-Jockschat Thomas Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Rottschy Claudia Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Thommes Johanna Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Schneider Frank Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Laird Angela Department of Physics, Florida International University, Miami, USA aut NATIONALLICENCE 700 1- Fox Peter Research Imaging Institute, University of Texas Health Sciences Center, San Antonio, USA aut NATIONALLICENCE 700 1- Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2355-2371 1863-2653 220:4<2355 2015 220 429