caa a22 4500 606202560 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0782-0 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0782-0 5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus [Elektronische Daten] [J. Kruschwitz, M. Walter, D. Varikuti, J. Jensen, M. Plichta, L. Haddad, O. Grimm, S. Mohnke, L. Pöhland, B. Schott, A. Wold, T. Mühleisen, A. Heinz, S. Erk, N. Romanczuk-Seiferth, S. Witt, M. Nöthen, M. Rietschel, A. Meyer-Lindenberg, H. Walter] The s/s-genotype of the 5-HTTLPR polymorphism and the personality trait of neuroticism have both been associated with experiences of negative affect, anxiety and mood disorders, as well as an emotional processing bias towards negative facial emotions. On a neural level, this bias can be characterized by altered amygdala and fusiform gyrus (FFG) activity during perception of negative facial expressions. Using resting-state functional magnetic resonance imaging in a multi-center-sample of 178 healthy subjects of European descent, this study investigated the association of 5-HTTLPR (short s- and long l-allele) including the genotype of the single nucleotide polymorphism (SNP) rs25531 (A/G) within this region polymorphism, and trait neuroticism on resting-state functional connectivity (rs-FC) between amygdala and the FFG. Moreover, we aimed to identify additional brain regions with associations of 5-HTTLPR/rs25531 (combined according to its expression; low: s/s; high: lA/lA; intermediate: s/lA, s/lG, lG/lG, lA/lG) and trait neuroticism to amygdala rs-FC. Separate analyses for 5-HTTLPR/rs25531 and neuroticism (controlling for age, gender, handedness, and research site) revealed that s/s-homozygotes and individuals high in neuroticism obtained altered amygdala rs-FC in the right occipital face area, which is considered to be a "core component” of the face processing system. Importantly, effects of neuroticism were replicated across three independent research sites. Additionally, associations of 5-HTTLPR/rs25531 genotype and amygdala rs-FC were observed in the anterior and posterior cingulate cortex, whereas neuroticism was not related to rs-FC in these areas. The presented data implies that 5-HTTLPR/rs25531 variants and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus and suggests that variants of 5-HTTLPR/rs25531 genotype and different levels of neuroticism may partly account for altered processing of negative facial emotions. Springer-Verlag Berlin Heidelberg, 2014 5-HTTLPR/rs25531 nationallicence Neuroticism nationallicence Amygdala nationallicence Fusiform gyrus nationallicence fMRI nationallicence Resting-state nationallicence Kruschwitz J. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Walter M. Department of Psychiatry, University Hospital of Magdeburg, Magdeburg, Germany aut Varikuti D. Department of Psychiatry, University Hospital of Magdeburg, Magdeburg, Germany aut Jensen J. Centre for Psychology, Kristianstad University, Kristianstad, Sweden aut Plichta M. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut Haddad L. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut Grimm O. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut Mohnke S. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Pöhland L. Division of Neuroimaging Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, Germany aut Schott B. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Wold A. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Mühleisen T. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany aut Heinz A. Division of Neuroimaging Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, Germany aut Erk S. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Romanczuk-Seiferth N. Division of Neuroimaging Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, Germany aut Witt S. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut Nöthen M. Department of Genomics, Life & Brain Center, Bonn, Germany aut Rietschel M. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut Meyer-Lindenberg A. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut Walter H. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2373-2385 1863-2653 220:4<2373 2015 220 429 https://doi.org/10.1007/s00429-014-0782-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0782-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kruschwitz J. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Walter M. Department of Psychiatry, University Hospital of Magdeburg, Magdeburg, Germany aut NATIONALLICENCE 700 1- Varikuti D. Department of Psychiatry, University Hospital of Magdeburg, Magdeburg, Germany aut NATIONALLICENCE 700 1- Jensen J. Centre for Psychology, Kristianstad University, Kristianstad, Sweden aut NATIONALLICENCE 700 1- Plichta M. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut NATIONALLICENCE 700 1- Haddad L. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut NATIONALLICENCE 700 1- Grimm O. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut NATIONALLICENCE 700 1- Mohnke S. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Pöhland L. Division of Neuroimaging Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Schott B. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Wold A. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Mühleisen T. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany aut NATIONALLICENCE 700 1- Heinz A. Division of Neuroimaging Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Erk S. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Romanczuk-Seiferth N. Division of Neuroimaging Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Witt S. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut NATIONALLICENCE 700 1- Nöthen M. Department of Genomics, Life & Brain Center, Bonn, Germany aut NATIONALLICENCE 700 1- Rietschel M. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut NATIONALLICENCE 700 1- Meyer-Lindenberg A. Central Institute of Mental Health Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany aut NATIONALLICENCE 700 1- Walter H. Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy, Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2373-2385 1863-2653 220:4<2373 2015 220 429