caa a22 4500 606202579 CHVBK 20210128100953.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0793-x doi (NATIONALLICENCE)springer-10.1007/s00429-014-0793-x Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue [Elektronische Daten] [Richard Tomsett, Matt Ainsworth, Alexander Thiele, Mehdi Sanayei, Xing Chen, Marc Gieselmann, Miles Whittington, Mark Cunningham, Marcus Kaiser] Local field potentials (LFPs) sampled with extracellular electrodes are frequently used as a measure of population neuronal activity. However, relating such measurements to underlying neuronal behaviour and connectivity is non-trivial. To help study this link, we developed the Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX). We first identified a reduced neuron model that retained the spatial and frequency filtering characteristics of extracellular potentials from neocortical neurons. We then developed VERTEX as an easy-to-use Matlab tool for simulating LFPs from large populations (>100,000 neurons). A VERTEX-based simulation successfully reproduced features of the LFPs from an in vitro multi-electrode array recording of macaque neocortical tissue. Our model, with virtual electrodes placed anywhere in 3D, allows direct comparisons with the in vitro recording setup. We envisage that VERTEX will stimulate experimentalists, clinicians, and computational neuroscientists to use models to understand the mechanisms underlying measured brain dynamics in health and disease. The Author(s), 2014 Local field potential nationallicence Computational modelling nationallicence Gamma oscillation nationallicence Macaque nationallicence Neocortex nationallicence Microconnectome nationallicence Tomsett Richard School of Computing Science, Newcastle University, Claremont Tower, NE1 7RU, Newcastle upon Tyne, UK aut Ainsworth Matt Hull York Medical School, University of York, YO10 5DD, York, UK aut Thiele Alexander Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut Sanayei Mehdi Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut Chen Xing Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut Gieselmann Marc Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut Whittington Miles Hull York Medical School, University of York, YO10 5DD, York, UK aut Cunningham Mark Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut Kaiser Marcus School of Computing Science, Newcastle University, Claremont Tower, NE1 7RU, Newcastle upon Tyne, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2333-2353 1863-2653 220:4<2333 2015 220 429 https://doi.org/10.1007/s00429-014-0793-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0793-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomsett Richard School of Computing Science, Newcastle University, Claremont Tower, NE1 7RU, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Ainsworth Matt Hull York Medical School, University of York, YO10 5DD, York, UK aut NATIONALLICENCE 700 1- Thiele Alexander Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Sanayei Mehdi Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Chen Xing Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Gieselmann Marc Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Whittington Miles Hull York Medical School, University of York, YO10 5DD, York, UK aut NATIONALLICENCE 700 1- Cunningham Mark Institute of Neuroscience, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Kaiser Marcus School of Computing Science, Newcastle University, Claremont Tower, NE1 7RU, Newcastle upon Tyne, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2333-2353 1863-2653 220:4<2333 2015 220 429