caa a22 4500 606202668 CHVBK 20210128100954.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0843-4 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0843-4 Shah N. Institute of Neuroscience and Medicine-4, Research Centre Jülich, 52425, Jülich, Germany aut Multimodal neuroimaging in humans at 9.4T: a technological breakthrough towards an advanced metabolic imaging scanner [Elektronische Daten] [N. Shah] The aim of this paper is twofold: firstly, to explore the potential of simultaneously acquiring multimodal MR-PET-EEG data in a human 9.4T scanner to provide a platform for metabolic brain imaging. Secondly, to demonstrate that the three modalities are complementary, with MRI providing excellent structural and functional imaging, PET providing quantitative molecular imaging, and EEG providing superior temporal resolution. A 9.4T MRI scanner equipped with a PET insert and a commercially available EEG device was used to acquire in vivo proton-based images, spectra, and sodium- and oxygen-based images with MRI, EEG signals from a human subject in a static 9.4T magnetic field, and demonstrate hybrid MR-PET capability in a rat model. High-resolution images of the in vivo human brain with an isotropic resolution of 0.5mm and post-mortem brain images of the cerebellum with an isotropic resolution of 320µm are presented. A 1H spectrum was also acquired from 2×2×2mm voxel in the brain allowing 12 metabolites to be identified. Imaging based on sodium and oxygen is demonstrated with isotropic resolutions of 2 and 5mm, respectively. Auditory evoked potentials measured in a static field of 9.4T are shown. Finally, hybrid MR-PET capability at 9.4T in the human scanner is demonstrated in a rat model. Initial progress on the road to 9.4T multimodal MR-PET-EEG is illustrated. Ultra-high resolution structural imaging, high-resolution images of the sodium distribution and proof-of-principle 17O data are clearly demonstrated. Further, simultaneous MR-PET data are presented without artefacts and EEG data successfully corrected for the cardioballistic artefact at 9.4T are presented. Springer-Verlag Berlin Heidelberg, 2014 Ultra-high field MRI nationallicence MRI-PET nationallicence PET nationallicence Metabolic imaging nationallicence Multimodal MR-PET-EEG nationallicence Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1867-1884 1863-2653 220:4<1867 2015 220 429 https://doi.org/10.1007/s00429-014-0843-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0843-4 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Shah N. Institute of Neuroscience and Medicine-4, Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1867-1884 1863-2653 220:4<1867 2015 220 429