caa a22 4500 606202692 CHVBK 20210128100954.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0786-9 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0786-9 Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain [Elektronische Daten] [Hans-Gert Bernstein, Jonathan Lindquist, Gerburg Keilhoff, Henrik Dobrowolny, Sabine Brandt, Johann Steiner, Bernhard Bogerts, Peter Mertens] The two cold shock domain containing proteins, Y-box-binding protein-1 and cold shock domain protein A were immunolocalized in developing and adult human brain. With the exception of a small population of hypothalamic astrocytes, brain Y-box-binding protein-1 was predominantly found in multiple neurons in the mature human CNS, which might be related to its involvement in neurotransmission and other neuron-associated functions. Cold shock domain protein A was typically observed in astrocytes, oligodendrocytes, choroid plexus epithelia and nerve fibers. However, in circumscribed brain regions as hypothalamus, habenula, and cerebellum, this protein was also expressed in neurons. In the prenatal brain, both proteins were found to be abundantly expressed in radial glial cells, neuroblasts and neurons, which might be an anatomical correlate of the proposed roles of both proteins in cell proliferation and differentiation. In addition, Y-box-binding protein-1 was identified in cultured, lipopolysaccharide-stimulated microglial cells, which underscores its putative role as a mediator in immune and inflammatory processes. Springer-Verlag Berlin Heidelberg, 2014 Y-box-binding protein 1 nationallicence Cold shock domain protein nationallicence Developing human brain nationallicence Adult human brain nationallicence Immunohistochemistry nationallicence Aka : Also known as nationallicence CD5 : Cluster of differentiation (glycoprotein) 5 nationallicence Cgl : Corpus geniculatum laterale nationallicence CNS : Central nervous system nationallicence CSD : Cold shock domain nationallicence DbPA : DNA binding protein A nationallicence DbPB : DNA binding protein B nationallicence DMEM : Dulbecco's modified Eagle medium nationallicence DNA : Deoxyribonucleic acid nationallicence DIV : Days in vitro (Days in culture) nationallicence FCS : Fetal calf serum nationallicence GFAP : Glial fibrillary acidic protein nationallicence GnRH : Gonadotropin releasing hormone nationallicence LPS : Lipopolysaccharide nationallicence mRNPs : Messenger ribonucleoprotein particles nationallicence MSY4 : Murine sequence-specific RNA binding protein nationallicence NSEP-1 : Nuclease sensitive element binding protein 1 nationallicence PVN : Paraventricular nucleus nationallicence RNA : Ribonucleic acid nationallicence rpm : Rotations per minute nationallicence SON : Supraoptic nucleus nationallicence YB-1 : Y-box-binding protein 1 nationallicence ZONAB : Zonula occludens 1 (ZO-1)-associated nucleic acid binding protein nationallicence Bernstein Hans-Gert Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut Lindquist Jonathan Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany aut Keilhoff Gerburg Faculty of Medicine, Institute of Biochemistry and Cell Biology, Otto-von-Guericke University, Magdeburg, Germany aut Dobrowolny Henrik Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut Brandt Sabine Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany aut Steiner Johann Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut Bogerts Bernhard Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut Mertens Peter Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2235-2245 1863-2653 220:4<2235 2015 220 429 https://doi.org/10.1007/s00429-014-0786-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0786-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bernstein Hans-Gert Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Lindquist Jonathan Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Keilhoff Gerburg Faculty of Medicine, Institute of Biochemistry and Cell Biology, Otto-von-Guericke University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Dobrowolny Henrik Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Brandt Sabine Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany aut NATIONALLICENCE 700 1- Steiner Johann Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Bogerts Bernhard Department of Psychiatry, Medical School, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Mertens Peter Department of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2235-2245 1863-2653 220:4<2235 2015 220 429